دورية أكاديمية
Fifteen Years of Iodine Prophylaxis in Italy: Results of a Nationwide Surveillance (Period 2015-2019).
| العنوان: | Fifteen Years of Iodine Prophylaxis in Italy: Results of a Nationwide Surveillance (Period 2015-2019). |
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| المؤلفون: | De Angelis S; Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, Rome 00161, Italy., Medda E; Reference Center for Behavioral Sciences and Mental Health, Italian National Institute of Health, Rome 00161, Italy., Rotondi D; Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, Rome 00161, Italy., Masocco M; National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome 00161, Italy., Minardi V; National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome 00161, Italy., Contoli B; National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome 00161, Italy., Possenti V; National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome 00161, Italy., Sorbo A; Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, Rome 00161, Italy., D'Amato M; Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, Rome 00161, Italy., Turco AC; Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, Rome 00161, Italy., Pastorelli AA; Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, Rome 00161, Italy., Stacchini P; Department of Food Safety, Nutrition and Veterinary Public Health, Italian National Institute of Health, Rome 00161, Italy., Cas RD; National Centre for Drug Research and Evaluation, Italian National Institute of Health, Rome 00161, Italy., Bagnasco M; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa 16132, Italy., Bonofiglio D; Department of Pharmacy, Health and Nutritional Sciences, Centro Sanitario, University of Calabria, Cosenza 87036, Italy., Gasperi M; Department of Medicine and Health Sciences 'V. Tiberio,' University of Molise, Campobasso 86100, Italy., Meringolo D; Endocrinology Unit, Ramazzini Institute, Bologna 40138, Italy., Mian C; Department of Medicine, University of Padua, Padua 35128, Italy., Moleti M; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy., Vermiglio F; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy., Puxeddu E; Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy., Taccaliti A; Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60126, Italy., Tonacchera M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56124, Italy., Ulisse S; Department of Surgery, 'Sapienza' University of Rome, Rome 00185, Italy., Dimida A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56124, Italy., Rago T; Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56124, Italy., Nazzari E; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa 16132, Italy., Schiavo M; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa 16132, Italy., Bossert I; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa 16132, Italy., Sturniolo G; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy., Corbetta C; Department of Woman, Mother and Neonate, 'Vittore Buzzi' Children's Hospital, Milan 20154, Italy., Cereda C; Department of Pediatrics, 'Vittore Buzzi' Children's Hospital, Milan 20154, Italy., Cappelletti L; Department of Pediatrics, 'Vittore Buzzi' Children's Hospital, Milan 20154, Italy., Camilot M; Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona 37134, Italy., Teofoli F; Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona 37134, Italy., Ciatti R; Azienda Ospedaliera Ospedali Riuniti Marche Nord, Presidio Ospedaliero Santa Croce, Fano 61032, Italy., Tarsi E; Azienda Ospedaliera Ospedali Riuniti Marche Nord, Presidio Ospedaliero Santa Croce, Fano 61032, Italy., Perrotti N; Department of Health Sciences, University Magna Graecia, Catanzaro 88100, Italy., Marasco O; Regional Neonatal Screening Laboratory, Azienda Ospedaliera Mater Domini, Catanzaro 88100, Italy., Scozzafava G; Regional Neonatal Screening Laboratory, Azienda Ospedaliera Mater Domini, Catanzaro 88100, Italy., Righetti F; Regional Laboratory for Neonatal Screening and Endocrine-Metabolic Diseases, IRCCS University Sant'Orsola Hospital, Bologna 40138, Italy., Andò S; Department of Pharmacy, Health and Nutritional Sciences, Centro Sanitario, University of Calabria, Cosenza 87036, Italy., Catalano S; Department of Pharmacy, Health and Nutritional Sciences, Centro Sanitario, University of Calabria, Cosenza 87036, Italy.; Annunziata Hospital, Cosenza 87100, Italy., Cristofaro M; S.C. Diabetes and Endocrine Diseases, Cardarelli Hospital, Campobasso 86100, Italy., Sorrenti G; Endocrinology Unit, Ramazzini Institute, Bologna 40138, Italy., Censi S; Department of Medicine, University of Padua, Padua 35128, Italy., Morelli S; Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy., Baldini E; Department of Surgery, 'Sapienza' University of Rome, Rome 00185, Italy., Plutino G; General Direction of Food Safety and Nutrition, Italian Ministry of Health, Rome 00144, Italy., Copparoni R; General Direction of Food Safety and Nutrition, Italian Ministry of Health, Rome 00144, Italy., Alonzo E; Food Hygiene and Nutrition Service-SIAN, Local Health Authority of Catania, Catania 95027, Italy., Giacomozzi C; Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, Rome 00161, Italy., Silano M; Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, Rome 00161, Italy., Olivieri A; Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Italian National Institute of Health, Rome 00161, Italy. |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Jan 18; Vol. 109 (2), pp. e495-e507. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | Goiter*/epidemiology , Goiter*/prevention & control , Iodine* , Hyperthyroidism*, Adult ; Female ; Infant ; Pregnancy ; Infant, Newborn ; Humans ; Child ; Methimazole ; Sodium Chloride, Dietary ; Italy/epidemiology ; Prevalence ; Thyrotropin |
| مستخلص: | Context: In 2005, a nationwide program of iodine prophylaxis on a voluntary basis was implemented in Italy by law. However, recent data on iodine status are lacking. Objective: The aim of this study was to evaluate efficiency, effectiveness, and possible adverse effects (increased occurrence of thyroid autoimmunity and hyperthyroidism) of the Italian iodine prophylaxis program. Methods: From 2015 to 2019, a nationwide survey was performed. The use of iodized salt was evaluated in a sample of 164 593 adults and in 998 school canteens. A sample of 4233 schoolchildren (aged 11-13 years) was recruited to assess urinary iodine concentration, prevalence of goiter, and thyroid hypoechogenicity on ultrasound, with the latter being an indirect indicator of thyroid autoimmunity. Neonatal TSH values of 197 677 infants screened in regions representative of Northern, Central, and Southern Italy were analyzed to investigate the percentage of TSH values >5.0 mIU/L. Data on methimazole prescriptions were analyzed as indirect indicators of new cases of hyperthyroidism. Results: The prevalence of the use of iodized salt was 71.5% in adult population and 78% in school canteens. A median urinary iodine concentration of 124 μg/L, a prevalence of goiter of 2.2%, and a prevalence of thyroid hypoechogenicity of 5.7% were observed in schoolchildren. The percentage of neonatal TSH values >5.0 mIU/L resulted still higher (5.1%) than the World Health Organization threshold of 3.0%, whereas the prescriptions of methimazole showed a reduction of 13.5%. Conclusion: Fifteen years of iodine prophylaxis have led to iodine sufficiency in Italy, although there still is concern about iodine nutritional status during pregnancy. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.) |
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| معلومات مُعتمدة: | cod 8AIC2 Ricerca Corrente of the Istituto Superiore di Sanità; cod ISS 6M69 Ministero della Salute |
| فهرسة مساهمة: | Keywords: iodine; iodine prophylaxis; iodized salt; surveillance; thyroid |
| المشرفين على المادة: | 0 (iodized salt) 554Z48XN5E (Methimazole) 0 (Sodium Chloride, Dietary) 9679TC07X4 (Iodine) 9002-71-5 (Thyrotropin) |
| تواريخ الأحداث: | Date Created: 20231011 Date Completed: 20240119 Latest Revision: 20240121 |
| رمز التحديث: | 20240121 |
| مُعرف محوري في PubMed: | PMC10795908 |
| DOI: | 10.1210/clinem/dgad593 |
| PMID: | 37820735 |
| قاعدة البيانات: | MEDLINE |
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