دورية أكاديمية
Don't eat me/eat me signals as a novel strategy in cancer immunotherapy.
العنوان: | Don't eat me/eat me signals as a novel strategy in cancer immunotherapy. |
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المؤلفون: | Khalaji A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Yancheshmeh FB; Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Farham F; Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Khorram A; Department of Laboratory Sciences, School of Allied Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran., Sheshbolouki S; Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran., Zokaei M; Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology/National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Veterinary Medicine, Beyza Branch, Islamic Azad University, Beyza, Iran., Vatankhah F; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Soleymani-Goloujeh M; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. |
المصدر: | Heliyon [Heliyon] 2023 Sep 29; Vol. 9 (10), pp. e20507. Date of Electronic Publication: 2023 Sep 29 (Print Publication: 2023). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: London : Elsevier Ltd, [2015]- |
مستخلص: | Cancer stands as one of the prominent global causes of death, with its incidence burden continuously increasing, leading to a substantial rise in mortality rates. Cancer treatment has seen the development of various strategies, each carrying its drawbacks that can negatively impact the quality of life for cancer patients. The challenge remains significant within the medical field to establish a definitive cancer treatment that minimizes complications and limitations. In the forthcoming years, exploring new strategies to surmount the failures in cancer treatment appears to be an unavoidable pursuit. Among these strategies, immunology-based ones hold substantial promise in combatting cancer and immune-related disorders. A particular subset of this approach identifies "eat me" and "Don't eat me" signals in cancer cells, contrasting them with their counterparts in non-cancerous cells. This distinction could potentially mark a significant breakthrough in treating diverse cancers. By delving into signal transduction and engineering novel technologies that utilize distinct "eat me" and "Don't eat me" signals, a valuable avenue may emerge for advancing cancer treatment methodologies. Macrophages, functioning as vital components of the immune system, regulate metabolic equilibrium, manage inflammatory disorders, oversee fibrosis, and aid in the repair of injuries. However, in the context of tumor cells, the overexpression of "Don't eat me" signals like CD47, PD-L1, and beta-2 microglobulin (B2M), an anti-phagocytic subunit of the primary histocompatibility complex class I, enables these cells to evade macrophages and proliferate uncontrollably. Conversely, the presentation of an "eat me" signal, such as Phosphatidylserine (PS), along with alterations in charge and glycosylation patterns on the cellular surface, modifications in intercellular adhesion molecule-1 (ICAM-1) epitopes, and the exposure of Calreticulin and PS on the outer layer of the plasma membrane represent universally observed changes on the surface of apoptotic cells, preventing phagocytosis from causing harm to adjacent non-tumoral cells. The current review provides insight into how signaling pathways and immune cells either stimulate or obstruct these signals, aiming to address challenges that may arise in future immunotherapy research. A potential solution lies in combination therapies targeting the "eat me" and "Don't eat me" signals in conjunction with other targeted therapeutic approaches. This innovative strategy holds promise as a novel avenue for the future treatment of cancer. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
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فهرسة مساهمة: | Keywords: Cancer; Don't eat me signal; Eat me signal; Immunotherapy; Phagocytosis |
تواريخ الأحداث: | Date Created: 20231012 Latest Revision: 20231018 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10562801 |
DOI: | 10.1016/j.heliyon.2023.e20507 |
PMID: | 37822610 |
قاعدة البيانات: | MEDLINE |
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