دورية أكاديمية
أعرض في EDS

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.

التفاصيل البيبلوغرافية
العنوان: ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.
المؤلفون: O'Sullivan J; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Kothari C; CHU de Québec Research Center, CHUL Pavilion, Oncology Division, Laval University Cancer Research Center, 2705 Boulevard Laurier, Québec City, QCG1V 4G2, Canada., Caron MC; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Gagné JP; CHU de Québec Research Center, CHUL Pavilion, Oncology Division, Laval University Cancer Research Center, 2705 Boulevard Laurier, Québec City, QCG1V 4G2, Canada., Jin Z; Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada., Nonfoux L; CHU de Québec Research Center, CHUL Pavilion, Oncology Division, Laval University Cancer Research Center, 2705 Boulevard Laurier, Québec City, QCG1V 4G2, Canada., Beneyton A; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Coulombe Y; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Thomas M; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Atalay N; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Meng XW; Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA., Milano L; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Jean D; Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada., Boisvert FM; Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada., Kaufmann SH; Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA., Hendzel MJ; Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada., Masson JY; CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Laval University Cancer Research Center, 9 McMahon, Québec City, QCG1R 3S3, Canada., Poirier GG; CHU de Québec Research Center, CHUL Pavilion, Oncology Division, Laval University Cancer Research Center, 2705 Boulevard Laurier, Québec City, QCG1V 4G2, Canada.
المصدر: Nucleic acids research [Nucleic Acids Res] 2023 Nov 10; Vol. 51 (20), pp. 11056-11079.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Poly Adenosine Diphosphate Ribose*/metabolism , Poly ADP Ribosylation*, Humans ; DNA/genetics ; DNA/metabolism ; DNA Damage ; DNA Repair ; Poly (ADP-Ribose) Polymerase-1/metabolism
مستخلص: Zinc finger (ZNF) motifs are some of the most frequently occurring domains in the human genome. It was only recently that ZNF proteins emerged as key regulators of genome integrity in mammalian cells. In this study, we report a new role for the Krüppel-type ZNF-containing protein ZNF432 as a novel poly(ADP-ribose) (PAR) reader that regulates the DNA damage response. We show that ZNF432 is recruited to DNA lesions via DNA- and PAR-dependent mechanisms. Remarkably, ZNF432 stimulates PARP-1 activity in vitro and in cellulo. Knockdown of ZNF432 inhibits phospho-DNA-PKcs and increases RAD51 foci formation following irradiation. Moreover, purified ZNF432 preferentially binds single-stranded DNA and impairs EXO1-mediated DNA resection. Consequently, the loss of ZNF432 in a cellular system leads to resistance to PARP inhibitors while its overexpression results in sensitivity. Taken together, our results support the emerging concept that ZNF-containing proteins can modulate PARylation, which can be embodied by the pivotal role of ZNF432 to finely balance the outcome of PARPi response by regulating homologous recombination.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)
References: Cancer Lett. 2020 Jan 1;468:48-58. (PMID: 31605774)
Cell Cycle. 2013 Aug 15;12(16):2675-83. (PMID: 23907130)
NPJ Breast Cancer. 2021 Aug 31;7(1):111. (PMID: 34465787)
EMBO J. 2019 Sep 16;38(18):e101220. (PMID: 31403225)
Cell. 2010 Apr 16;141(2):243-54. (PMID: 20362325)
Trends Biochem Sci. 2019 Mar;44(3):226-240. (PMID: 30638972)
Cell Rep. 2018 Aug 28;24(9):2493-2505.e4. (PMID: 30157440)
Nucleic Acids Res. 2020 Apr 6;48(6):3001-3013. (PMID: 31965183)
Mol Cell. 2016 Feb 4;61(3):405-418. (PMID: 26774285)
Elife. 2018 Feb 26;7:. (PMID: 29480802)
Cell Death Discov. 2017 Nov 13;3:17071. (PMID: 29152378)
Front Genet. 2022 Jul 18;13:887088. (PMID: 35923694)
Nat Commun. 2021 Oct 8;12(1):5893. (PMID: 34625544)
Med Oncol. 2021 Aug 25;38(10):118. (PMID: 34432161)
Trends Genet. 2018 Apr;34(4):313-325. (PMID: 29370947)
J Exp Med. 2020 Nov 2;217(11):. (PMID: 32865561)
J Biol Chem. 2007 Jun 1;282(22):16441-53. (PMID: 17428792)
Sci Rep. 2017 Mar 06;7:43530. (PMID: 28262757)
PLoS One. 2014 Mar 19;9(3):e92155. (PMID: 24647005)
Nucleic Acids Res. 2022 Jul 5;50(W1):W216-W221. (PMID: 35325185)
Anal Biochem. 1995 May 1;227(1):1-13. (PMID: 7668367)
Nat Commun. 2018 May 22;9(1):2016. (PMID: 29789535)
Mol Cell Proteomics. 2019 May;18(5):1010-1026. (PMID: 30798302)
Genes Dev. 1996 Aug 15;10(16):2067-78. (PMID: 8769649)
Gynecol Oncol. 2019 Apr;153(1):127-134. (PMID: 30686551)
Cell Rep. 2015 Jun 9;11(9):1486-500. (PMID: 26004182)
Semin Cell Dev Biol. 2021 May;113:65-74. (PMID: 32962915)
Cell Rep. 2020 Sep 22;32(12):108176. (PMID: 32966781)
Nucleic Acids Res. 2023 Jun 23;51(11):5364-5376. (PMID: 36951113)
Trends Mol Med. 2021 Jul;27(7):630-642. (PMID: 34030964)
Nucleic Acids Res. 2019 Dec 2;47(21):11250-11267. (PMID: 31566235)
Oncogene. 2020 Jan;39(4):754-766. (PMID: 31570788)
Cancer Discov. 2013 Jan;3(1):68-81. (PMID: 23103855)
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18475-80. (PMID: 20937877)
PLoS One. 2014 Jan 21;9(1):e86010. (PMID: 24465839)
Cell Rep. 2015 Apr 7;11(1):149-63. (PMID: 25818296)
Trends Biochem Sci. 2007 Feb;32(2):63-70. (PMID: 17210253)
Mol Cell. 2021 Nov 4;81(21):4552-4567.e8. (PMID: 34551281)
Nature. 2018 Nov;563(7732):522-526. (PMID: 30464262)
Nat Commun. 2021 Nov 18;12(1):6675. (PMID: 34795260)
Nat Cell Biol. 2006 Aug;8(8):870-6. (PMID: 16862143)
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):. (PMID: 33692124)
Front Cell Dev Biol. 2020 Sep 09;8:564601. (PMID: 33015058)
Mol Cell. 2019 Jul 11;75(1):145-153.e5. (PMID: 31153714)
Sci Adv. 2020 Dec 18;6(51):. (PMID: 33355125)
J Vis Exp. 2021 Apr 28;(170):. (PMID: 33999036)
Genes Dev. 2019 Jan 1;33(1-2):75-89. (PMID: 30567999)
Nat Cell Biol. 2012 Feb 19;14(3):318-28. (PMID: 22344029)
Nucleic Acids Res. 2018 Feb 16;46(3):1266-1279. (PMID: 29244158)
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. (PMID: 30476243)
J Biol Chem. 2008 Aug 8;283(32):21873-80. (PMID: 18539602)
Nat Commun. 2021 Nov 12;12(1):6560. (PMID: 34772923)
Genome Res. 2016 Dec;26(12):1742-1752. (PMID: 27852650)
Nat Methods. 2013 Oct;10(10):981-4. (PMID: 23955771)
Nature. 2008 Jan 3;451(7174):81-5. (PMID: 18172500)
Mol Cell. 2017 Mar 2;65(5):932-940.e6. (PMID: 28190768)
Sci Adv. 2017 May 24;3(5):e1601898. (PMID: 28560323)
Mol Cell. 2000 Oct;6(4):757-68. (PMID: 11090615)
Cell Cycle. 2013 Jul 1;12(13):2033-41. (PMID: 23777805)
Genome Biol. 2003;4(10):231. (PMID: 14519192)
Mol Cell. 2013 Mar 7;49(5):858-71. (PMID: 23333305)
Nat Commun. 2019 Jul 4;10(1):2954. (PMID: 31273204)
J Comput Aided Mol Des. 2018 Jun;32(6):657-669. (PMID: 29725908)
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489. (PMID: 33237286)
Cell Cycle. 2013 Sep 1;12(17):2817-28. (PMID: 23966166)
Cancer Res. 2006 Dec 15;66(24):11594-9. (PMID: 17178852)
Mol Cell. 2017 Mar 2;65(5):777-778. (PMID: 28257697)
J Allergy Clin Immunol. 2014 Mar;133(3):723-8.e3. (PMID: 24280104)
Nucleic Acids Res. 2014 Feb;42(3):e19. (PMID: 24362840)
Acta Naturae. 2017 Apr-Jun;9(2):47-58. (PMID: 28740726)
معلومات مُعتمدة: P50 CA136393 United States CA NCI NIH HHS
المشرفين على المادة: 9007-49-2 (DNA)
EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
26656-46-2 (Poly Adenosine Diphosphate Ribose)
0 (zinc finger protein 432, human)
تواريخ الأحداث: Date Created: 20231012 Date Completed: 20231117 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10639050
DOI: 10.1093/nar/gkad791
PMID: 37823600
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkad791