دورية أكاديمية
Neo-Natal Castration Leads to Subtle Differences in Porcine Anterior Cruciate Ligament Morphology and Function in Adolescence.
| العنوان: | Neo-Natal Castration Leads to Subtle Differences in Porcine Anterior Cruciate Ligament Morphology and Function in Adolescence. |
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| المؤلفون: | Thompson JD; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina at Chapel Hill, Raleigh, NC 27695; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695., Howe D; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina at Chapel Hill, Raleigh, NC 27695; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695., Griffith EH; Department of Statistics, North Carolina State University, Raleigh, NC 27695., Fisher MB; Joint Department of Biomedical Engineering, North Carolina State University & University of North Carolina at Chapel Hill, 4130 Engineering Building III, 1840 Entrepreneur Drive, CB 7115, Raleigh, NC 27695; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695; Department of Orthopaedics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. |
| المصدر: | Journal of biomechanical engineering [J Biomech Eng] 2024 Jan 01; Vol. 146 (1). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society Of Mechanical Engineers Country of Publication: United States NLM ID: 7909584 Publication Model: Print Cited Medium: Internet ISSN: 1528-8951 (Electronic) Linking ISSN: 01480731 NLM ISO Abbreviation: J Biomech Eng Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : American Society Of Mechanical Engineers Original Publication: [New York] American Society of Mechanical Engineers. |
| مواضيع طبية MeSH: | Anterior Cruciate Ligament Injuries* , Knee Injuries*, Humans ; Adolescent ; Male ; Animals ; Swine ; Female ; Anterior Cruciate Ligament/physiology ; Anterior Cruciate Ligament/surgery ; Castration ; Testosterone ; Knee Joint/physiology |
| مستخلص: | Female adolescent athletes are at a higher risk of tearing their anterior cruciate ligament (ACL) than male counterparts. While most work related to hormones has focused on the effects of estrogen to understand the increased risk of ACL injury, there are other understudied factors, including testosterone. The purpose of this study was to determine how surgical castration in the male porcine model influences ACL size and function across skeletal growth. Thirty-six male Yorkshire crossbreed pigs were raised to 3 (juvenile), 4.5 (early adolescent), and 6 months (adolescent) of age. Animals were either castrated (barrows) within 2 weeks after birth or were left intact (boars). Posteuthanasia, joint and ACL size were assessed via MRI, and biomechanics were assessed via a robotic testing system. Joint size increased throughout age, yet barrows had smaller joints than boars. ACL cross-sectional area (CSA), length, volume, and in situ stiffness increased with age, as did the percent contribution of the ACL anteromedial (AM) bundle to resisting loads. Boar ACL, AM bundle, and PL bundle volumes were 19%, 25%, and 15% larger than barrows across ages. However, ACL CSA, in situ stiffness, and bundle contribution were similar between boars and barrows. The barrows had smaller temporal increases in AM bundle function than boars, but these data were highly variable. Early and sustained loss in testosterone leads to subtle differences in ACL morphology but may not influence measures associated with increased injury risk, such as CSA or bundle forces in response to applied loads. (Copyright © 2024 by ASME.) |
| التعليقات: | Update of: bioRxiv. 2023 Feb 15:2023.01.24.524954. doi: 10.1101/2023.01.24.524954. (PMID: 36747760) |
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| معلومات مُعتمدة: | F31 AR077997 United States AR NIAMS NIH HHS; R01 AR071985 United States AR NIAMS NIH HHS; F31AR077997 United States AR NIAMS NIH HHS; R01AR071985 United States AR NIAMS NIH HHS |
| المشرفين على المادة: | 3XMK78S47O (Testosterone) |
| تواريخ الأحداث: | Date Created: 20231013 Date Completed: 20231106 Latest Revision: 20240618 |
| رمز التحديث: | 20240618 |
| مُعرف محوري في PubMed: | PMC10680984 |
| DOI: | 10.1115/1.4063744 |
| PMID: | 37831117 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1528-8951 |
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| DOI: | 10.1115/1.4063744 |