دورية أكاديمية
Distribution of pharmacogene allele and phenotype frequencies in Brazilian psychiatric patients.
| العنوان: | Distribution of pharmacogene allele and phenotype frequencies in Brazilian psychiatric patients. |
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| المؤلفون: | May GB; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., de Souza BR; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Gueuvoghlanian-Silva BY; Innovation Department, Hospital Israelita Albert Einstein, São Paulo, SP, 05652-900, Brazil., Dos Reis EC; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Mostardeiro SR; Universidade do Sul de Santa Catarina (UNISUL)-Campus Pedra Branca, Palhoça, SC, 88137-270, Brazil., Boabaid May PP; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Mateo EC; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil., Vietta GG; Universidade do Sul de Santa Catarina (UNISUL)-Campus Pedra Branca, Palhoça, SC, 88137-270, Brazil., Hoss GW; Laboratório GnTech, Florianópolis, SC, 88015-200, Brazil. |
| المصدر: | Pharmacogenomics [Pharmacogenomics] 2023 Sep; Vol. 24 (14), pp. 747-760. Date of Electronic Publication: 2023 Oct 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 100897350 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8042 (Electronic) Linking ISSN: 14622416 NLM ISO Abbreviation: Pharmacogenomics Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Future Medicine Ltd Original Publication: London : Ashley Publications, |
| مواضيع طبية MeSH: | Pharmacogenetics*, Humans ; Alleles ; Brazil ; Cross-Sectional Studies ; Phenotype |
| مستخلص: | Purpose: This work was designed to identify the pharmacogenetic profile of Brazilian psychiatric patients receiving psychoactive drug treatment according to ethnicity. Methods: Based on the GnTech ® database, this cross-sectional study analyzed data from self-reported sociodemographic and genetic results from the next-generation sequencing panel composed of 26 pharmacogenes from 359 psychotropic drug users. Results: Variant frequencies of multiple pharmacogenes presented differences between ethnicities ( CYP3A5 , CYP2D6 , CYP1A2 , CYP2B6 , CYP3A4 , UGT1A4 , UGT2B15 , ABCB1 rs1045642 , ADRA2A rs1800544 , COMT rs4680 , GRIK4 rs1954787 , GSK3B rs334558 , GSK3B rs6438552 , HTR1A rs6295 , HTR2A rs7997012 , HTR2C rs1414334 , MTHFR rs1801131 , OPRM1 rs1799971 and 5-HTTLPR ), endorsing the necessity of individual-level analyses in drug treatment. Conclusion: A discussion of pharmacogenomic test implementation in psychiatric clinical practice is needed to improve treatment choices, especially in Brazil, a multiethnic country. |
| فهرسة مساهمة: | Keywords: ethnicity; genetic frequencies; haplotype; mental disorders; pharmacogenomic test; single-nucleotide variants |
| تواريخ الأحداث: | Date Created: 20231017 Date Completed: 20231102 Latest Revision: 20231102 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2217/pgs-2023-0075 |
| PMID: | 37846556 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-8042 |
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| DOI: | 10.2217/pgs-2023-0075 |