دورية أكاديمية
Intravenous ketorolac versus metoclopramide in adult patients with migraine headaches: An updated systematic review and meta-analysis.
| العنوان: | Intravenous ketorolac versus metoclopramide in adult patients with migraine headaches: An updated systematic review and meta-analysis. |
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| المؤلفون: | Song Q; Department of Neurology, Tangshan Fengrun People's Hospital, China., Yang H; Tangshan Fengrun District Liujiaying Health Center, China., Yang X; Disinfection Supply Center, Tangshan Fengrun District People's Hospital, China. |
| المصدر: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University [Adv Clin Exp Med] 2024 Jul; Vol. 33 (7), pp. 661-667. |
| نوع المنشور: | Systematic Review; Journal Article; Meta-Analysis; Review; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: The University Country of Publication: Poland NLM ID: 101138582 Publication Model: Print Cited Medium: Print ISSN: 1899-5276 (Print) Linking ISSN: 18995276 NLM ISO Abbreviation: Adv Clin Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wroclaw, Poland : The University, |
| مواضيع طبية MeSH: | Metoclopramide*/administration & dosage , Metoclopramide*/adverse effects , Metoclopramide*/therapeutic use , Migraine Disorders*/drug therapy , Ketorolac*/administration & dosage , Ketorolac*/adverse effects , Ketorolac*/therapeutic use , Administration, Intravenous* , Anti-Inflammatory Agents, Non-Steroidal*/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal*/adverse effects , Anti-Inflammatory Agents, Non-Steroidal*/therapeutic use, Humans ; Adult ; Randomized Controlled Trials as Topic ; Treatment Outcome |
| مستخلص: | Background: Intravenous ketorolac and metoclopramide are common emergency treatments for adult patients with migraine headaches. The comparison between ketorolac and metoclopramide for migraine treatment is an intriguing issue for research and clinical practice. Objectives: To provide an updated systematic review and meta-analysis of randomized clinical trials (RCTs) to help determine which treatment has better effects for migraine patients. Material and Methods: Intravenous ketorolac and metoclopramide were compared to evaluate whether intravenous ketorolac is associated with significant benefits for pain intensity, short-term headache relief and sustained headache relief among adult patients with migraines. Adverse effects were also analyzed. Five studies with a total of 674 adult patients were included in the analysis, which focused on the outcomes of pain intensity, short-term headache relief, sustained headache relief, and adverse effects. Results: The meta-analysis showed that the only modest but statistically significant difference was present in short-term headache relief when comparing intravenous ketorolac with intravenous metoclopramide. There were no significant differences between intravenous ketorolac and metoclopramide in terms of pain intensity, sustained headache relief or adverse effects. Conclusion: The results suggest that there are no significant differences in most treatment effects (aside from short-term headache relief) and adverse effects when comparing intravenous ketorolac with intravenous metoclopramide. However, the paucity of literature on this topic might have limited the interpretation of the current results. Thus, more relevant studies are warranted. |
| فهرسة مساهمة: | Keywords: intravenous; ketorolac; meta-analysis; metoclopramide; migraine |
| المشرفين على المادة: | L4YEB44I46 (Metoclopramide) YZI5105V0L (Ketorolac) 0 (Anti-Inflammatory Agents, Non-Steroidal) |
| تواريخ الأحداث: | Date Created: 20231018 Date Completed: 20240730 Latest Revision: 20240730 |
| رمز التحديث: | 20240730 |
| DOI: | 10.17219/acem/171697 |
| PMID: | 37849443 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1899-5276 |
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| DOI: | 10.17219/acem/171697 |