دورية أكاديمية
Low pre-albumin but not thiamine predicts cognitive deficits in adolescents post-Fontan and healthy controls.
| العنوان: | Low pre-albumin but not thiamine predicts cognitive deficits in adolescents post-Fontan and healthy controls. |
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| المؤلفون: | Pike NA; University of California Los Angeles, School of Nursing, Los Angeles, CA, USA.; Department of Cardiothoracic Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA., Avedissian T; American University of Beirut, Hariri School of Nursing, Beirut, Lebanon., Halnon NH; Department of Pediatric Cardiology, UCLA Mattel Children's Hospital, Los Angeles, CA, USA., Lewis AB; Department of Pediatric Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA., Kumar R; Departments of Anesthesiology and Radiological Sciences, University of California, Los Angeles, CA, USA. |
| المصدر: | Cardiology in the young [Cardiol Young] 2024 Apr; Vol. 34 (4), pp. 803-808. Date of Electronic Publication: 2023 Oct 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 9200019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-1107 (Electronic) Linking ISSN: 10479511 NLM ISO Abbreviation: Cardiol Young Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Cambridge : Cambridge University Press Original Publication: Chapel Hill, NC : World Publishers, c1991- |
| مواضيع طبية MeSH: | Cognition Disorders*/blood , Cognition Disorders*/diagnosis , Cognition Disorders*/etiology , Fontan Procedure*/adverse effects , Heart Defects, Congenital*/surgery , Thiamine*/analysis , Serum Albumin*/analysis, Adolescent ; Adult ; Child ; Female ; Humans ; Cognition ; Cross-Sectional Studies |
| مستخلص: | Background: Low pre-albumin, body mass index, and thiamine levels have been associated with poor nutritional status and cognitive/memory deficits in adult heart failure patients. However, the relationship of these nutritional/dietary intake biomarkers to cognition has not been assessed in adolescents post-Fontan procedure and healthy controls. Methods: This is a cross-sectional study. Adolescents (14-21 years of age) post-Fontan completion were recruited from paediatric cardiology clinics and controls from the community. The Montreal Cognitive Assessment was administered (normal ≥ 26), and blood draw (thiamine [normal 70-110 nmol/L] and pre-albumin levels [adolescent normal 23-45 mg/dL]) and the Thiamine Food Frequency Questionnaire were completed by all participants. Results: Seventy subjects, 40 post-Fontan (mean age 16 ± 1.6, female 51%, Hispanic 44%, hypoplastic left heart syndrome 26%) and 30 controls (mean age 16.8 ± 1.9, female 52%, Hispanic 66%), were participated. Post-Fontan group had lower median total cognitive scores (23 versus 29, p < 0.001), pre-albumin levels (23 versus 27, p = 0.013), and body mass index (20 versus 24, p = 0.027) than controls. Post-Fontan group had higher thiamine levels than controls (127 versus 103, p = 0.033). Lower pre-albumin levels (< 23) and underweight body mass index were associated with abnormal total cognitive scores (p = 0.030). Low pre-albumin level (p = .038) was an independent predictor of worse cognition. Conclusion: Lower pre-albumin was an independent predictor for worse cognition in adolescents post-Fontan. Lower pre-albumin levels may reflect chronic liver changes or protein-losing enteropathy seen in Fontan physiology. These findings highlight the possibility for nutrition-induced cognitive changes. |
| فهرسة مساهمة: | Keywords: CHD; albumin; neurodevelopmental; single ventricle |
| المشرفين على المادة: | X66NSO3N35 (Thiamine) 0 (Serum Albumin) |
| تواريخ الأحداث: | Date Created: 20231018 Date Completed: 20240416 Latest Revision: 20240429 |
| رمز التحديث: | 20240429 |
| DOI: | 10.1017/S1047951123003396 |
| PMID: | 37850442 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1467-1107 |
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| DOI: | 10.1017/S1047951123003396 |