دورية أكاديمية
Copper ion-based chemical elicitation induces production of new benzofurans in Anthostomella brabeji, an endophytic fungus of Paepalanthus planifolius.
| العنوان: | Copper ion-based chemical elicitation induces production of new benzofurans in Anthostomella brabeji, an endophytic fungus of Paepalanthus planifolius. |
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| المؤلفون: | Hilario F; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Road Araraquara-Jaú km 1, Araraquara 14800-903, Brazil., Polinário G; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Road Araraquara-Jaú km 1, Araraquara 14800-903, Brazil., de Amorim MR; Institute of Chemistry, São Paulo State University (UNESP), Av. Prof. Francisco Degni n.55, Araraquara 14800-060, Brazil., Botero WB; Institute of Chemistry, São Paulo State University (UNESP), Av. Prof. Francisco Degni n.55, Araraquara 14800-060, Brazil., Peixoto T; Institute of Chemistry, São Paulo State University (UNESP), Av. Prof. Francisco Degni n.55, Araraquara 14800-060, Brazil., Paz TA; School of Pharmaceutical Sciences of Ribeirao Preto (FCFRP), University of São Paulo (USP), Av. do Café, s/n°, Ribeirão Preto, 14040-903, Brazil., Furlan M; Institute of Chemistry, São Paulo State University (UNESP), Av. Prof. Francisco Degni n.55, Araraquara 14800-060, Brazil., de Luca Batista AN; Institute of Chemistry, Fluminense Federal University (UFF), Outeiro de São João Batista s/n, Niterói 24020-141, Brazil., Junior JMB; Institute of Science and Technology, Federal University of São Paulo (UNIFESP), Rua Talim n. 330, São José dos Campos 12231-280, Brazil., Bauab TM; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Road Araraquara-Jaú km 1, Araraquara 14800-903, Brazil. Electronic address: tais.bauab@unesp.br., Dos Santos LC; Institute of Chemistry, São Paulo State University (UNESP), Av. Prof. Francisco Degni n.55, Araraquara 14800-060, Brazil. Electronic address: lourdes.campaner@unesp.br. |
| المصدر: | Fitoterapia [Fitoterapia] 2023 Dec; Vol. 171, pp. 105706. Date of Electronic Publication: 2023 Oct 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Eriocaulaceae* , Ascomycota*, Copper ; Molecular Structure ; Plant Extracts/chemistry |
| مستخلص: | The present work reports the effects of chemical elicitors and epigenetic modifiers on the production and diversification of secondary metabolites produced by Anthostomella brabeji - an endophytic fungus isolated from Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated under four different small-scale culture conditions in potato dextrose broth (PDB): PDB (control), PDB + Mg +2 , PDB + Cu +2 and PDB + 5-AZA (5-azacytidine). The incorporation of Cu +2 into PDB medium yielded the most promising results as the most significant differences in the metabolic profile of A. brabeji were observed under this condition. The chemical analysis of the PDB + Cu +2 extract resulted in the isolation of seven metabolites, including three new benzofuran derivatives (2, 4 and 6) and four known compounds (1, 3, 5 and 7). The metabolites were tested using the Gram-positive bacterium Staphylococcus aureus, Gram-negative bacteria Salmonella sp. and Escherichia coli, and six yeasts of Candida albicans and non-albicans. The EtOAc extract (PDB + Cu +2 ), and compounds 1, 2 and 7 exhibited relevant antifungal activity against Candida spp., with minimum inhibitory concentration ranging from 62.5 to 500.0 μg/mL. Competing Interests: Declaration of Competing Interest None. (Copyright © 2023. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Benzofurans; Chemical elicitation; Fungal metabolites; Natural products; Paepalanthus planifolius |
| المشرفين على المادة: | 789U1901C5 (Copper) 0 (Plant Extracts) |
| SCR Organism: | Anthostomelloides brabeji |
| تواريخ الأحداث: | Date Created: 20231018 Date Completed: 20231127 Latest Revision: 20231127 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.fitote.2023.105706 |
| PMID: | 37852387 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6971 |
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| DOI: | 10.1016/j.fitote.2023.105706 |