دورية أكاديمية
Single basolateral amygdala neurons in macaques exhibit distinct connectional motifs with frontal cortex.
| العنوان: | Single basolateral amygdala neurons in macaques exhibit distinct connectional motifs with frontal cortex. |
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| المؤلفون: | Zeisler ZR; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., London L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Janssen WG; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Microscopy and Advanced Bioimaging CoRE, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Fredericks JM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Elorette C; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Fujimoto A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zhan H; Cold Spring Harbor Laboratory, 1 Bungtown Road, Syosset, NY 11791, USA., Russ BE; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA; Department of Psychiatry, New York University at Langone, One, 8 Park Avenue, New York, NY 10016, USA., Clem RL; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA., Hof PR; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA., Stoll FM; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rudebeck PH; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: peter.rudebeck@mssm.edu. |
| المصدر: | Neuron [Neuron] 2023 Oct 18; Vol. 111 (20), pp. 3307-3320.e5. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Basolateral Nuclear Complex*/physiology, Animals ; Macaca ; Neural Pathways/physiology ; Frontal Lobe ; Neurons/physiology ; Prefrontal Cortex/physiology |
| مستخلص: | Basolateral amygdala (BLA) projects widely across the macaque frontal cortex, and amygdalo-frontal projections are critical for appropriate emotional responding and decision making. While it is appreciated that single BLA neurons branch and project to multiple areas in frontal cortex, the organization and frequency of this branching has yet to be fully characterized. Here, we determined the projection patterns of more than 3,000 macaque BLA neurons. We found that one-third of BLA neurons had two or more distinct projection targets in frontal cortex and subcortical structures. The patterns of single BLA neuron projections to multiple areas were organized into repeating motifs that targeted distinct sets of areas in medial and ventral frontal cortex, indicative of separable BLA networks. Our findings begin to reveal the rich structure of single-neuron connections in the non-human primate brain, providing a neuroanatomical basis for the role of BLA in coordinating brain-wide responses to valent stimuli. Competing Interests: Declaration of interests The authors have no disclosures to report. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| التعليقات: | Update of: bioRxiv. 2023 Feb 20;:. (PMID: 36711708) |
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| معلومات مُعتمدة: | R01 MH116445 United States MH NIMH NIH HHS; R01 MH124880 United States MH NIMH NIH HHS; R34 NS122050 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: amygdala; collaterals; connectivity; connectomics; mRNA; macaque; sequencing; tract tracing |
| تواريخ الأحداث: | Date Created: 20231019 Date Completed: 20231023 Latest Revision: 20240509 |
| رمز التحديث: | 20240509 |
| مُعرف محوري في PubMed: | PMC10593429 |
| DOI: | 10.1016/j.neuron.2023.09.024 |
| PMID: | 37857091 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4199 |
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| DOI: | 10.1016/j.neuron.2023.09.024 |