دورية أكاديمية
The pathophysiology of the cell cycle in cancer and treatment strategies using various cell cycle checkpoint inhibitors.
| العنوان: | The pathophysiology of the cell cycle in cancer and treatment strategies using various cell cycle checkpoint inhibitors. |
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| المؤلفون: | Almalki SG; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia. Electronic address: Samialmalki1402@gmail.com. |
| المصدر: | Pathology, research and practice [Pathol Res Pract] 2023 Nov; Vol. 251, pp. 154854. Date of Electronic Publication: 2023 Oct 04. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fischer Verlag Original Publication: Stuttgart, New York, Fischer. |
| مواضيع طبية MeSH: | Mitosis* , Neoplasms*/drug therapy, Humans ; Cell Cycle ; DNA Replication ; Cell Cycle Checkpoints ; DNA |
| مستخلص: | The cell cycle is the series of events that occur in a cell leading to its division and duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the longest stage of the cell cycle and can be further divided into three phases: G1, S, and G2. During G1, the cell grows and prepares for DNA synthesis. In the S phase, DNA synthesis occurs, leading to the replication of the genetic material. In G2, the cell continues to grow and prepares for mitosis. After mitosis, the cell enters the final stage of the cell cycle, called cytokinesis, during which the cytoplasm is divided, resulting in two separate daughter cells. The cell cycle then begins again with interphase. Cell cycle dysregulation is a hallmark of cancer, and it can have several consequences that contribute to the development and progression of cancer. Cyclin inhibitors and checkpoint activators have shown promise in the treatment of cancer, particularly in combination with other therapies. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cancer; Cell cycle; Checkpoint; Cyclin |
| المشرفين على المادة: | 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 20231021 Date Completed: 20231113 Latest Revision: 20231113 |
| رمز التحديث: | 20231113 |
| DOI: | 10.1016/j.prp.2023.154854 |
| PMID: | 37864989 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1618-0631 |
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| DOI: | 10.1016/j.prp.2023.154854 |