دورية أكاديمية
أعرض في EDS

The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury.

التفاصيل البيبلوغرافية
العنوان: The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury.
المؤلفون: Lee H; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA., Lee TJ; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA., Galloway CA; Department of Pathology and Laboratory Medicine, and Center for Advanced Research Technologies, University of Rochester Medical Center, Rochester, NY, 14642, USA., Zhi W; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA., Xiao W; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA., de Mesy Bentley KL; Department of Pathology and Laboratory Medicine, and Center for Advanced Research Technologies, University of Rochester Medical Center, Rochester, NY, 14642, USA., Sharma A; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA., Teng Y; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA., Sesaki H; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Yoon Y; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA. yyoon@augusta.edu.
المصدر: Nature communications [Nat Commun] 2023 Oct 23; Vol. 14 (1), pp. 6721. Date of Electronic Publication: 2023 Oct 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Mitochondrial Proteins*/genetics , Mitochondrial Proteins*/metabolism , Mitochondrial Dynamics*, Male ; Animals ; Mice ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; Mitochondria/metabolism ; Liver/metabolism
مستخلص: Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping. Disruption of OPA1 causes mitochondrial dysfunction. However, the role of OPA1 in liver function is poorly understood. In this study, we delete OPA1 in the fully developed liver of male mice. Unexpectedly, OPA1 liver knockout (LKO) mice are healthy with unaffected mitochondrial respiration, despite disrupted cristae morphology. OPA1 LKO induces a stress response that establishes a new homeostatic state for sustained liver function. Our data show that OPA1 is required for proper complex V assembly and that OPA1 LKO protects the liver from drug toxicity. Mechanistically, OPA1 LKO decreases toxic drug metabolism and confers resistance to the mitochondrial permeability transition. This study demonstrates that OPA1 is dispensable in the liver, and that the mitohormesis induced by OPA1 LKO prevents liver injury and contributes to liver resiliency.
(© 2023. Springer Nature Limited.)
References: Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8. (PMID: 20616029)
Nature. 2020 Mar;579(7799):427-432. (PMID: 32132707)
Elife. 2021 May 04;10:. (PMID: 33944779)
Hum Mol Genet. 2007 Jun 1;16(11):1307-18. (PMID: 17428816)
Cell. 2006 Jul 14;126(1):177-89. (PMID: 16839885)
J Biol Chem. 2005 Jul 15;280(28):26185-92. (PMID: 15899901)
J Biol Chem. 2008 May 16;283(20):13565-77. (PMID: 18337250)
EMBO J. 2012 May 2;31(9):2117-33. (PMID: 22433842)
Cell Metab. 2020 May 5;31(5):987-1003.e8. (PMID: 32315597)
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10190-5. (PMID: 21646527)
EMBO J. 2008 Jan 23;27(2):433-46. (PMID: 18200046)
EMBO J. 2018 May 15;37(10):. (PMID: 29632021)
iScience. 2022 Feb 26;25(4):103996. (PMID: 35310936)
EMBO J. 2017 Jul 14;36(14):2126-2145. (PMID: 28607005)
J Clin Invest. 2022 Jul 15;132(14):. (PMID: 35700042)
Biotechniques. 2013 Sep;55(3):133-6. (PMID: 24003945)
Biochim Biophys Acta. 2008 Sep;1777(9):1092-7. (PMID: 18519024)
EMBO J. 2014 Mar 18;33(6):578-93. (PMID: 24550258)
Gene Ther. 2013 Apr;20(4):460-4. (PMID: 22895507)
Biochem Soc Trans. 2016 Dec 15;44(6):1725-1735. (PMID: 27913683)
Brain. 2008 Feb;131(Pt 2):338-51. (PMID: 18158317)
Mol Biol Cell. 2011 Jul 1;22(13):2235-45. (PMID: 21551073)
Chem Biol Interact. 1984 Mar;48(3):349-66. (PMID: 6713598)
J Cell Biol. 2003 Jan 20;160(2):189-200. (PMID: 12527753)
Nat Cell Biol. 2011 May;13(5):589-98. (PMID: 21478857)
Animal Model Exp Med. 2020 Dec 18;3(4):304-315. (PMID: 33532705)
Therap Adv Gastroenterol. 2021 Jul 27;14:17562848211031394. (PMID: 34377148)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Cell Death Differ. 2013 Feb;20(2):353-65. (PMID: 23138851)
Cell Metab. 2013 Apr 2;17(4):491-506. (PMID: 23562075)
EMBO Rep. 2016 Oct;17(10):1374-1395. (PMID: 27629041)
Front Mol Biosci. 2021 Nov 23;8:772174. (PMID: 34888354)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
Cell Commun Signal. 2010 Dec 22;8:31. (PMID: 21176168)
Elife. 2013 May 28;2:e00498. (PMID: 23741617)
Bioinformatics. 2014 Feb 15;30(4):523-30. (PMID: 24336805)
Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1105-14. (PMID: 19706786)
Biochem J. 2003 Mar 15;370(Pt 3):751-62. (PMID: 12467494)
Int J Biochem Cell Biol. 2009 Oct;41(10):1855-65. (PMID: 19389487)
J Gerontol A Biol Sci Med Sci. 2006 Feb;61(2):107-14. (PMID: 16510854)
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9893-8. (PMID: 8790427)
J Cell Biol. 2009 Sep 21;186(6):805-16. (PMID: 19752021)
Elife. 2020 May 28;9:. (PMID: 32463360)
Diabetes. 2014 Dec;63(12):4057-63. (PMID: 25008183)
Nat Genet. 2000 Oct;26(2):211-5. (PMID: 11017080)
Science. 2013 Jun 28;340(6140):1567-70. (PMID: 23812712)
Mol Ther. 2008 Jun;16(6):1081-8. (PMID: 18414478)
Semin Liver Dis. 2019 May;39(2):221-234. (PMID: 30849782)
EMBO J. 2014 Dec 1;33(23):2798-813. (PMID: 25349190)
Int J Biochem Cell Biol. 2018 Feb;95:93-99. (PMID: 29288054)
Gene Expr. 2020 Nov 11;20(2):125-138. (PMID: 32443984)
Annu Rev Physiol. 2016;78:505-31. (PMID: 26667075)
Hepatology. 2018 Dec;68(6):2167-2181. (PMID: 29698569)
Biosci Biotechnol Biochem. 2016 May;80(5):929-34. (PMID: 27010621)
Toxicol Appl Pharmacol. 2014 Nov 15;281(1):58-66. (PMID: 25218290)
J Cell Sci. 2009 Nov 1;122(Pt 21):3823-30. (PMID: 19889967)
Nat Genet. 2000 Oct;26(2):207-10. (PMID: 11017079)
Mol Cell Biol. 1999 May;19(5):3435-42. (PMID: 10207067)
Brain. 2010 Mar;133(Pt 3):771-86. (PMID: 20157015)
Endocrinology. 2008 Dec;149(12):6018-27. (PMID: 18687777)
Nat Med. 2013 Jan;19(1):83-92. (PMID: 23202295)
Cell Metab. 2017 Jun 6;25(6):1374-1389.e6. (PMID: 28552492)
Cell Metab. 2014 May 6;19(5):757-66. (PMID: 24561260)
Toxicol Appl Pharmacol. 2013 Jun 15;269(3):240-9. (PMID: 23571099)
J Biol Chem. 2017 Apr 28;292(17):7115-7130. (PMID: 28298442)
Nat Cell Biol. 2009 Aug;11(8):958-66. (PMID: 19578372)
J Adv Pract Oncol. 2013 Jul;4(4):263-8. (PMID: 25032007)
Diabetes. 2009 Jan;58(1):250-9. (PMID: 18840786)
Cell Metab. 2015 Jun 2;21(6):845-54. (PMID: 26039449)
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10853-8. (PMID: 19541642)
Anal Chim Acta. 2012 May 21;727:8-12. (PMID: 22541816)
Ann Neurol. 2006 Feb;59(2):265-75. (PMID: 16365880)
Front Physiol. 2019 Apr 17;10:419. (PMID: 31057418)
Biochimie. 2013 Apr;95(4):692-9. (PMID: 23123503)
Gastroenterology. 2018 Sep;155(3):629-647. (PMID: 30012333)
EMBO J. 2014 Nov 18;33(22):2676-91. (PMID: 25298396)
Cell Metab. 2015 Jun 2;21(6):834-44. (PMID: 26039448)
Curr Opin Toxicol. 2018 Feb;7:44-51. (PMID: 29527583)
Sci Adv. 2020 Jun 24;6(26):eaba7509. (PMID: 32637615)
Hepatology. 2004 Nov;40(5):1170-9. (PMID: 15486922)
J Biol Chem. 2020 May 8;295(19):6543-6560. (PMID: 32245890)
Ann Neurol. 2005 Dec;58(6):958-63. (PMID: 16240368)
Cell Metab. 2018 Oct 2;28(4):588-604.e5. (PMID: 30017357)
Orphanet J Rare Dis. 2017 May 12;12(1):89. (PMID: 28494813)
Cell Metab. 2014 Dec 2;20(6):1069-75. (PMID: 25470551)
EMBO J. 2021 Nov 2;40(21):e108648. (PMID: 34542926)
J Cell Biol. 2002 Jun 24;157(7):1151-60. (PMID: 12082077)
J Cell Biol. 2014 Mar 17;204(6):919-29. (PMID: 24616225)
Nature. 2020 Mar;579(7799):433-437. (PMID: 32132706)
Cell Signal. 2011 Oct;23(10):1534-45. (PMID: 21683788)
Cell. 2010 Apr 16;141(2):280-9. (PMID: 20403324)
Genes Dev. 2012 Feb 1;26(3):271-81. (PMID: 22302939)
معلومات مُعتمدة: R21 EY031483 United States EY NEI NIH HHS; R03 DE032084 United States DE NIDCR NIH HHS; R35 GM144103 United States GM NIGMS NIH HHS; R01 DE028351 United States DE NIDCR NIH HHS; R01 HL093671 United States HL NHLBI NIH HHS; R56 DK136753 United States DK NIDDK NIH HHS
المشرفين على المادة: 0 (Mitochondrial Proteins)
EC 3.6.1.- (GTP Phosphohydrolases)
تواريخ الأحداث: Date Created: 20231023 Date Completed: 20231027 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10593833
DOI: 10.1038/s41467-023-42564-0
PMID: 37872238
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-42564-0