دورية أكاديمية
Age, Sperm Retrieval, and Testicular Histology in Klinefelter Syndrome.
| العنوان: | Age, Sperm Retrieval, and Testicular Histology in Klinefelter Syndrome. |
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| المؤلفون: | Kang C; Department of Urology, Weill Cornell Medicine, New York, New York.; Department of Urology, Atrium Health Carolinas Medical Center, Charlotte, North Carolina., Punjani N; Department of Urology, Weill Cornell Medicine, New York, New York.; Department of Urology, Mayo Clinic, Phoenix, Arizona., Kashanian JA; Department of Urology, Weill Cornell Medicine, New York, New York., Schlegel PN; Department of Urology, Weill Cornell Medicine, New York, New York. |
| المصدر: | The Journal of urology [J Urol] 2024 Jan; Vol. 211 (1), pp. 163-169. Date of Electronic Publication: 2023 Oct 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 0376374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3792 (Electronic) Linking ISSN: 00225347 NLM ISO Abbreviation: J Urol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : [Philadelphia, PA] : Wolters Kluwer Original Publication: Baltimore : Lippincott Williams & Wilkins |
| مواضيع طبية MeSH: | Klinefelter Syndrome*/complications , Klinefelter Syndrome*/pathology , Azoospermia*/pathology, Adult ; Adolescent ; Humans ; Male ; Young Adult ; Testis/pathology ; Sperm Retrieval ; Semen ; Spermatozoa ; Retrospective Studies |
| مستخلص: | Purpose: We sought to examine sperm retrieval and testicular histology in males of different ages with Klinefelter syndrome. Materials and Methods: We identified all males with Klinefelter syndrome who underwent microdissection testicular sperm extraction at our institution from 1995 to 2020. Patients were divided into adolescent (<20 years) and adult (≥20 years) cohorts. Histology and sperm retrieval were compared using chi-square statistics. Multivariable logistic regression models were used to examine factors associated with successful sperm retrieval. Results: We identified 217 males with Klinefelter syndrome, of whom 59 were adolescents and 158 were adults. Adults were stratified into 10-year groupings (20-29 years, n = 62; 30-39 years, n = 88; ≥40 years, n = 8). Approximately 17% of adolescents had testis histology containing germ cells compared with 15% of the 20 to 29-year cohort, 14% of the 30 to 39-year cohort, and 0% over 40 years. In comparison to adolescents (53%), the sperm retrieval rate was significantly higher in the 20 to 29-year cohort (71%, P = .04) and lower in the ≥40-year cohort (13%, P = .03). In multivariable analysis, the presence of hypospermatogenesis on testis biopsy (OR 5.8, P = .03) was associated with higher odds of successful sperm retrieval. Conclusions: Younger males more frequently had germ cell-containing testis histology, however this finding was not associated with a higher odds of sperm retrieval. Reproductive urologists should counsel azoospermic males with Klinefelter syndrome that sperm retrieval during adolescence for fertility preservation is not required and can be performed in young adulthood. |
| التعليقات: | Comment in: J Urol. 2024 Jan;211(1):169. doi: 10.1097/JU.0000000000003737.01. (PMID: 37873936) |
| فهرسة مساهمة: | Keywords: Klinefelter syndrome; male infertility; testicular sperm retrieval |
| تواريخ الأحداث: | Date Created: 20231024 Date Completed: 20231216 Latest Revision: 20240625 |
| رمز التحديث: | 20240625 |
| DOI: | 10.1097/JU.0000000000003737 |
| PMID: | 37873937 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1527-3792 |
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| DOI: | 10.1097/JU.0000000000003737 |