دورية أكاديمية
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Genomic epidemiology reveals the dominance of Hennepin County in the transmission of SARS-CoV-2 in Minnesota from 2020 to 2022.

التفاصيل البيبلوغرافية
العنوان: Genomic epidemiology reveals the dominance of Hennepin County in the transmission of SARS-CoV-2 in Minnesota from 2020 to 2022.
المؤلفون: Scotch M; Research Affiliate, Mayo Clinic, Phoenix, Arizona, USA.; Biodesign Institute, Arizona State University, Tempe, Arizona, USA.; College of Health Solutions, Arizona State University, Phoenix, Arizona, USA., Lauer K; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Wieben ED; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA., Cherukuri Y; Research Services, Mayo Clinic, Jacksonville, Florida, USA., Cunningham JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Klee EW; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.; Center for Individualized Medicine, Rochester, Minnesota, USA., Harrington JJ; Center for Individualized Medicine, Rochester, Minnesota, USA., Lau JS; Center for Individualized Medicine, Rochester, Minnesota, USA., McDonough SJ; Center for Individualized Medicine, Rochester, Minnesota, USA., Mutawe M; Center for Individualized Medicine, Rochester, Minnesota, USA., O'Horo JC; Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota, USA., Rentmeester CE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.; Saint Mary's University of Minnesota, Winona, Minnesota, USA., Schlicher NR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., White VT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Schneider SK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Vedell PT; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Wang X; Minnesota Department of Health, St. Paul, Minnesota, USA., Yao JD; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Pritt BS; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Norgan AP; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
المصدر: MSphere [mSphere] 2023 Dec 20; Vol. 8 (6), pp. e0023223. Date of Electronic Publication: 2023 Oct 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101674533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-5042 (Electronic) Linking ISSN: 23795042 NLM ISO Abbreviation: mSphere Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Society for Microbiology, [2015]-
مواضيع طبية MeSH: SARS-CoV-2*/genetics , COVID-19*/epidemiology, Humans ; Minnesota/epidemiology ; Pandemics ; Communicable Disease Control ; Genomics
مستخلص: Importance: We analyzed over 22,000 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes of patient samples tested at Mayo Clinic Laboratories during a 2-year period in the COVID-19 pandemic, which included Alpha, Delta, and Omicron variants of concern to examine the roles and relationships of Minnesota virus transmission. We found that Hennepin County, the most populous county, drove the transmission of SARS-CoV-2 viruses in the state after including the formation of earlier clades including 20A, 20C, and 20G, as well as variants of concern Alpha and Delta. We also found that Hennepin County was the source for most of the county-to-county introductions after an initial predicted introduction with the virus in early 2020 from an international source, while other counties acted as transmission "sinks." In addition, major policies, such as the end of the lockdown period in 2020 or the end of all restrictions in 2021, did not appear to have an impact on virus diversity across individual counties.
Competing Interests: The authors declare no conflict of interest.
التعليقات: Update of: medRxiv. 2023 Apr 26;:. (PMID: 35923324)
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معلومات مُعتمدة: R01 AI164481 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Minnesota; SARS-CoV-2; computational biology; epidemiology; high-throughput nucleotide sequencing
SCR Organism: SARS-CoV-2 variants
تواريخ الأحداث: Date Created: 20231026 Date Completed: 20231221 Latest Revision: 20240218
رمز التحديث: 20240218
مُعرف محوري في PubMed: PMC10871168
DOI: 10.1128/msphere.00232-23
PMID: 37882516
قاعدة البيانات: MEDLINE
الوصف
تدمد:2379-5042
DOI:10.1128/msphere.00232-23