دورية أكاديمية
Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam.
| العنوان: | Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam. |
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| المؤلفون: | Hujer AM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Marshall SH; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA., Mack AR; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Hujer KM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Bakthavatchalam YD; Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India., Umarkar K; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Palwe SR; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Takalkar S; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Joshi PR; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Shrivastava R; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Periasamy H; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Bhagwat SS; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Patel MV; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India., Bonomo RA; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Departments of Pharmacology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, and the CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA. |
| المصدر: | MBio [mBio] 2023 Dec 19; Vol. 14 (6), pp. e0111823. Date of Electronic Publication: 2023 Oct 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Society for Microbiology |
| مواضيع طبية MeSH: | Pseudomonas aeruginosa*/drug effects , Pseudomonas aeruginosa*/genetics , Anti-Bacterial Agents*/pharmacology , Azabicyclo Compounds*/pharmacology , Cyclooctanes*/pharmacology , Microbial Sensitivity Tests* , Cephalosporins*/pharmacology, Drug Resistance, Multiple, Bacterial/genetics ; beta-Lactamase Inhibitors/pharmacology ; Cefepime/pharmacology ; Pseudomonas Infections/microbiology ; Pseudomonas Infections/drug therapy ; beta-Lactams/pharmacology ; Humans ; beta-Lactamases/genetics ; beta-Lactamases/metabolism ; Drug Combinations ; Piperidines |
| مستخلص: | Compared to other genera of Gram-negative pathogens, Pseudomonas is adept in acquiring complex non-enzymatic and enzymatic resistance mechanisms thus remaining a challenge to even novel antibiotics including recently developed β-lactam and β-lactamase inhibitor combinations. This study shows that the novel β-lactam enhancer approach enables cefepime/zidebactam to overcome both non-enzymatic and enzymatic resistance mechanisms associated with a challenging panel of P. aeruginosa . This study highlights that the β-lactam enhancer mechanism is a promising alternative to the conventional β-lactam/β-lactamase inhibitor approach in combating ever-evolving MDR P. aeruginosa . Competing Interests: Some of the coauthors are employees of Wockhardt. R.A.B. receives grant funding from Wockhardt. |
| فهرسة مساهمة: | Keywords: Pseudomonas aeruginosa; antibiotic resistance; cefepime; zidebactam; ß-lactam enhancer; ß-lactamase inhibitor; ß-lactamases |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Azabicyclo Compounds) 0 (Cyclooctanes) 0 (Cephalosporins) 0 (beta-Lactamase Inhibitors) 807PW4VQE3 (Cefepime) 0 (cefepime-zidebactam) 0 (beta-Lactams) EC 3.5.2.6 (beta-Lactamases) 0 (zidebactam) 0 (Drug Combinations) 0 (Piperidines) |
| تواريخ الأحداث: | Date Created: 20231027 Date Completed: 20240727 Latest Revision: 20240727 |
| رمز التحديث: | 20240729 |
| مُعرف محوري في PubMed: | PMC10746216 |
| DOI: | 10.1128/mbio.01118-23 |
| PMID: | 37889005 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2150-7511 |
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| DOI: | 10.1128/mbio.01118-23 |