دورية أكاديمية
أعرض في EDS

Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study.

التفاصيل البيبلوغرافية
العنوان: Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study.
المؤلفون: Vasyukova E; Institute of Endocrinology, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia.; World-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia., Zaikova E; World-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia., Kalinina O; World-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia., Gorelova I; Department of Obstetrics and Gynecology, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia., Pyanova I; Institute of Endocrinology, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia., Bogatyreva E; Scandinavia AVA-PETER Clinic, 191014 Saint Petersburg, Russia., Vasilieva E; Central Clinical Diagnostic Laboratory, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia., Grineva E; Institute of Endocrinology, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia.; World-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia., Popova P; Institute of Endocrinology, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia.; World-Class Research Center for Personalized Medicine, Almazov National Medical Research Centre, 194156 Saint Petersburg, Russia.
المصدر: Biomedicines [Biomedicines] 2023 Oct 14; Vol. 11 (10). Date of Electronic Publication: 2023 Oct 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Background: it has been suggested that chronic low-grade inflammation plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). According to previous studies, it remains unclear which cytokines influence the development of this syndrome and whether their increase is associated with the presence of excess weight/obesity or is an independent factor. The aim of our research was to determine the parameters of chronic inflammation in women with PCOS in comparison with healthy women in the normal weight and the overweight subgroups.
Methods: This case-control study included 44 patients with PCOS (19 women with a body mass index (BMI) < 25 kg/m² and 25 women with a BMI ≥ 25 kg/m²) and 45 women without symptoms of PCOS (22 women with a BMI < 25 kg/m² and 23 women with a BMI ≥ 25 kg/m²). Thirty-two cytokines were analyzed in the plasma of the participants using Immunology multiplex assay HCYTA-60K-PX48 (Merck Life Science, LLC, Germany).
Results: Cytokines: interleukin-1 receptor antagonist (IL-1 RA), IL-2, IL-6, IL-17 E, IL-17 A, IL-18, and macrophage inflammatory protein-1 alpha (MIP-1 α) were increased in women with PCOS compared to controls, both in lean and overweight/obese subgroups ( p < 0.05). Moreover, only lean women with PCOS had higher levels of IL-1 alpha, IL-4, IL-9, IL-12, IL-13, IL-15, tumor necrosis factor (TNF- α) alpha and beta, soluble CD40 and its ligand (SCD40L), fractalkine (FKN), monocyte-chemotactic protein 3 (MCP-3), and MIP-1 β compared to the control group ( p < 0.05). IL-22 was increased in the combined group of women with PCOS (lean and overweight/obese) compared to the control group ( p = 0.012).
Conclusion: Chronic low-grade inflammation is an independent factor affecting the occurrence of PCOS and does not depend on the presence of excess weight/obesity. For the first time, we obtained data on the increase in such inflammatory parameters as IL-9, MCP-3, and MIP-1α in women with PCOS.
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معلومات مُعتمدة: 25 Almazov National Medical Research Center
فهرسة مساهمة: Keywords: FKN fractalkine; GROa; IL-1 RA; IL-1 α; IL-13; IL-15; IL-17E; IL-18; IL-2; IL-3; IL-4; IL-5; IL-6; IL-9; MCP-1; MCP-3; MIG; MIP-1 α; MIP-1 β; SCD40L; TNF α; TNF β
تواريخ الأحداث: Date Created: 20231028 Latest Revision: 20231030
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10604137
DOI: 10.3390/biomedicines11102791
PMID: 37893164
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines11102791