دورية أكاديمية
Clustered health risk behaviors with comorbid symptoms of anxiety and depression in young adults: Moderating role of inflammatory cytokines.
| العنوان: | Clustered health risk behaviors with comorbid symptoms of anxiety and depression in young adults: Moderating role of inflammatory cytokines. |
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| المؤلفون: | Wang M; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Li T; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Xie Y; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Zhang D; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Qu Y; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Zhai S; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Mou X; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Yang Y; School of Nursing, Anhui Medical University, 15 Feicui Road, Hefei 230601, Anhui, China., Zou L; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China., Tao S; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China., Tao F; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China., Wu X; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, China. Electronic address: xywu@ahmu.edu.cn. |
| المصدر: | Journal of affective disorders [J Affect Disord] 2024 Jan 15; Vol. 345, pp. 335-341. Date of Electronic Publication: 2023 Oct 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Health Risk Behaviors* , Depression*/epidemiology , Depression*/psychology, Adolescent ; Humans ; Young Adult ; Cytokines ; Anxiety/epidemiology ; Anxiety/psychology ; Comorbidity |
| مستخلص: | Background: People with multiple health risk behaviors (HRBs) are at higher risk for psychological problems, and vice versa. However, the mechanisms underlying this association remain unknown. Method: We collected questionnaire and blood sample data from 2 universities in Anhui and Jiangxi Provinces. Demographic information, HRBs and blood samples were collected at baseline. Depression/anxiety symptoms were collected using questionnaires at follow-up. Latent class analysis was used to explore clustered HRBs pattern, and logistic regression analysis was used to examine the association between clustered HRBs quantity, pattern and anxiety-depression symptoms comorbidity. The Mplus software was used to analyze the moderating effects of inflammatory cytokines. Results: Compared to the HRB low-risk group, the substance dependence group (OR: 1.89, 95%CI: 1.11-3.21) and sedentary group (OR: 2.98, 95%CI: 1.48-6.02) had a higher risk of anxiety-depression comorbid symptoms. Compared to participants with no clustered HRBs, participants with 2 HRBs (OR: 2.16 95%CI: 1.17-4.00) and >3 HRBs (OR: 3.55, 95%CI: 1.68-7.48) were more likely to suffer from comorbid symptoms of anxiety and depression. Moreover, IL-6, IL-1β, IL-10 had negative moderating effects between clustered HRBs pattern and comorbid symptoms of anxiety and depression. Limitations: Recall bias may exist for anxiety / depression symptoms, and cannot exclude unmeasured confounders or the effect of residual confounding. Conclusions: This study finds clustered HRBs have a significant impact on mental health among young adults, and inflammatory cytokine evidence supports a negative moderating effect on the relationship. Interventions that decrease clustered HRBs may support mental health development in adolescence. Competing Interests: Declaration of competing interest All authors declare no biomedical financial interests or potential conflicts of interest. (Copyright © 2023. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Anxiety; Comorbidity; Depression; Health risk behaviors; Inflammatory cytokines |
| المشرفين على المادة: | 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20231028 Date Completed: 20231123 Latest Revision: 20231205 |
| رمز التحديث: | 20231205 |
| DOI: | 10.1016/j.jad.2023.10.139 |
| PMID: | 37898475 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1573-2517 |
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| DOI: | 10.1016/j.jad.2023.10.139 |