دورية أكاديمية
Unique Cardiopulmonary Interactions in Congenital Diaphragmatic Hernia: Physiology and Therapeutic Implications.
| العنوان: | Unique Cardiopulmonary Interactions in Congenital Diaphragmatic Hernia: Physiology and Therapeutic Implications. |
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| المؤلفون: | Johng S; Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, Philadelphia, PA., Fraga MV; Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, Philadelphia, PA., Patel N; Department of Neonatology, Royal Hospital for Children, Glasgow, United Kingdom., Kipfmueller F; Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany., Bhattacharya A; Department of Neonatology, Royal Hospital for Children, Glasgow, United Kingdom., Bhombal S; Department of Pediatrics, Emory University/Children's Healthcare of Atlanta, Atlanta, GA. |
| المصدر: | NeoReviews [Neoreviews] 2023 Nov 01; Vol. 24 (11), pp. e720-e732. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 101085360 Publication Model: Print Cited Medium: Internet ISSN: 1526-9906 (Electronic) Linking ISSN: 15269906 NLM ISO Abbreviation: Neoreviews Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Washington, DC] : American Academy of Pediatrics Original Publication: [Elk Grove Village, IL] : [Standford, CA] : American Academy of Pediatrics ; Published with the assistance of Stanford University Libraries' HighWire Press, c2000- |
| مواضيع طبية MeSH: | Hernias, Diaphragmatic, Congenital*/therapy , Hypertension, Pulmonary*/diagnosis , Hypertension, Pulmonary*/etiology , Hypertension, Pulmonary*/therapy, Pregnancy ; Female ; Humans ; Lung/abnormalities |
| مستخلص: | Congenital diaphragmatic hernia (CDH) results in abdominal contents entering the thoracic cavity, affecting both cardiac and pulmonary development. Maldevelopment of the pulmonary vasculature occurs within both the ipsilateral lung and the contralateral lung. The resultant bilateral pulmonary hypoplasia and associated pulmonary hypertension are important components of the pathophysiology of this disease that affect outcomes. Despite prenatal referral to specialized high-volume centers, advanced ventilation strategies, pulmonary hypertension management, and the option of extracorporeal membrane oxygenation, overall CDH mortality remains between 25% and 30%. With increasing recognition that cardiac dysfunction plays a large role in morbidity and mortality in patients with CDH, it becomes imperative to understand the different clinical phenotypes, thus allowing for individual patient-directed therapies. Further research into therapeutic interventions that address the cardiopulmonary interactions in patients with CDH may lead to improved morbidity and mortality outcomes. (Copyright © 2023 by the American Academy of Pediatrics.) |
| تواريخ الأحداث: | Date Created: 20231031 Date Completed: 20231102 Latest Revision: 20231102 |
| رمز التحديث: | 20231102 |
| DOI: | 10.1542/neo.24-11-e720 |
| PMID: | 37907403 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1526-9906 |
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| DOI: | 10.1542/neo.24-11-e720 |