دورية أكاديمية
أعرض في EDS

Relationship of irisin expression with metabolic alterations and cardiovascular risk in type 2 diabetes mellitus: a preliminary study.

التفاصيل البيبلوغرافية
العنوان: Relationship of irisin expression with metabolic alterations and cardiovascular risk in type 2 diabetes mellitus: a preliminary study.
المؤلفون: Mathia VL; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Mendonça MIS; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Simões DP; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Perez MM; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Alves BDCA; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Encinas JFA; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Raimundo JRS; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Arcia CGC; Centro Universitário São Camilo - São Paulo (SP), Brazil., Murad N; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil., Fonseca FLA; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil.; Universidade Federal de São Paulo, Department of Pharmaceutical Sciences - Diadema (SP), Brazil., Veiga GLD; Centro Universitário FMABC, Clinical Analysis Laboratory - Santo André (SP), Brazil.
المصدر: Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2023 Oct 30; Vol. 69 (12), pp. e20230812. Date of Electronic Publication: 2023 Oct 30 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: São Paulo : Associação Médica Brasileira
مواضيع طبية MeSH: Cardiovascular Diseases*/complications , Diabetes Mellitus, Type 2*, Adult ; Humans ; Blood Glucose/metabolism ; Case-Control Studies ; Cross-Sectional Studies ; Fibronectins ; Glycated Hemoglobin ; Heart Disease Risk Factors ; Obesity/complications ; Risk Factors
مستخلص: Objective: The aim of this study was to investigate the role of irisin in type 2 diabetes mellitus and its association with metabolic alterations and obesity.
Methods: A cross-sectional case-control study was conducted on participants treated at Centro Universitário FMABC between August 2018 and July 2019, by comparing a control group (n=14) with type 2 diabetes mellitus patients (n=16). The control group consisted of participants aged above 21 years with no chronic diseases, diabetes, smoking, or illicit drug use. The type 2 diabetes mellitus group included patients aged above 21 years, who were diagnosed with type 2 diabetes for at least 5 years (glycated hemoglobin>7%). Exclusion criteria were not willing to continue, recent hospitalization, and failure to meet inclusion criteria. Biochemical parameters included blood glucose, glycated hemoglobin, plasma irisin levels, and irisin gene expression in peripheral blood.
Results: Type 2 diabetes mellitus patients exhibited significantly higher plasma glucose levels [143 (40) vs. 92 (13) mg/dL, *p<0.05] and glycated hemoglobin levels [7.1% (1.6) vs. 5.6% (0.5), *p<0.05] compared to the control group. Irisin gene expression in type 2 diabetes mellitus patients was lower 0.02288 (0.08050) than the control group 8.506e-006 (1.412e-005) (p=0.06). Correlation analysis revealed a positive association between irisin expression and body mass index in type 2 diabetes mellitus (Rho=0.5221, 95%CI -0.058 to 0.838, p=0.06), while plasma irisin showed a negative correlation with body mass index (Rho=-0.656, 95%CI -0.836 to 0.215, p=0.03). No significant correlations were found between plasma glucose or glycated hemoglobin levels and irisin expression.
Conclusion: The data suggests that body mass index directly influences plasma irisin levels and the regulation of irisin gene expression, possibly linking irisin to adiposity changes observed in obesity-related type 2 diabetes mellitus.
References: Platelets. 2008 Mar;19(2):111-4. (PMID: 17852772)
Mediators Inflamm. 2019 Apr 17;2019:9213074. (PMID: 31148950)
J Clin Endocrinol Metab. 2013 Dec;98(12):4899-907. (PMID: 24057291)
Pol Arch Med Wewn. 2016 Jul 25;126(7-8):474-82. (PMID: 27452672)
Int J Endocrinol. 2014;2014:857270. (PMID: 24864142)
Acta Diabetol. 2014 Oct;51(5):705-13. (PMID: 24619655)
Endocrine. 2018 Feb;59(2):260-274. (PMID: 29170905)
Diabetes Res Clin Pract. 2018 Feb;136:100-107. (PMID: 29199003)
Sci Rep. 2016 Jul 19;6:29898. (PMID: 27432282)
Q J Med. 1993 Nov;86(11):739-42. (PMID: 8265775)
Platelets. 2013;24(2):118-21. (PMID: 22494325)
Adv Sci (Weinh). 2021 Sep;8(18):e2100275. (PMID: 34319011)
Cells. 2019 Oct 19;8(10):. (PMID: 31635130)
Medicine (Baltimore). 2016 Jun;95(23):e3742. (PMID: 27281072)
J Pharmacopuncture. 2017 Dec;20(4):235-242. (PMID: 30151293)
J Bras Nefrol. 2020 Mar;42(1):47-52. (PMID: 31799981)
Ren Fail. 2016 Jul;38(6):914-9. (PMID: 27089215)
Eat Weight Disord. 2018 Aug;23(4):431-442. (PMID: 28933009)
Neurotherapeutics. 2018 Oct;15(4):1158-1167. (PMID: 30030698)
Biosci Rep. 2017 Jun 8;37(3):. (PMID: 28408433)
المشرفين على المادة: 0 (Blood Glucose)
0 (Fibronectins)
0 (Glycated Hemoglobin)
0 (FNDC5 protein, human)
تواريخ الأحداث: Date Created: 20231101 Date Completed: 20231103 Latest Revision: 20231103
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10615221
DOI: 10.1590/1806-9282.20230812
PMID: 37909533
قاعدة البيانات: MEDLINE
الوصف
تدمد:1806-9282
DOI:10.1590/1806-9282.20230812