دورية أكاديمية
Schizophrenia patients discharged on antipsychotic polypharmacy from a public psychiatric hospital in Taiwan, 2006-2021.
| العنوان: | Schizophrenia patients discharged on antipsychotic polypharmacy from a public psychiatric hospital in Taiwan, 2006-2021. |
|---|---|
| المؤلفون: | Lin CH; Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan., Huang CJ; Department of Psychiatry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Lin TC; Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Chan HY; Department of General Psychiatry, Taoyuan Psychiatric Center, Taoyuan, Taiwan; Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: jan30@seed.net.tw., Chen JJ; Department of General Psychiatry, Taoyuan Psychiatric Center, Taoyuan, Taiwan. |
| المصدر: | Psychiatry research [Psychiatry Res] 2023 Dec; Vol. 330, pp. 115575. Date of Electronic Publication: 2023 Oct 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier/North-Holland Biomedical Press Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Antipsychotic Agents*/therapeutic use , Schizophrenia*/drug therapy , Clozapine*/therapeutic use, Humans ; Male ; Female ; Polypharmacy ; Patient Discharge ; Hospitals, Psychiatric ; Taiwan |
| مستخلص: | The aim of this study was to identify the factors associated with antipsychotic polypharmacy (APP), investigate whether APP could affect the risk of rehospitalization, and explore temporal trends in APP use. Schizophrenia patients discharged from the study hospital between 2006 and 2021 (n = 16,722) were included in the analysis. The logistic regression model was employed to determine the predictors significantly associated with APP use. Survival analysis was used to compare time to rehospitalization between APP and antipsychotic monotherapy (AMT). The temporal trend of APP use was analyzed using the Cochran-Armitage Trend test. In comparison with the patients (n = 10,909) who were discharged on AMT, those (n = 5,813) on APP were significantly more likely to be male gender, to receive LAIs, to take clozapine, to take anticholinergic agents, to have a greater number of previous hospitalizations, and to have a higher CPZ equivalent dose of antipsychotic prescription. The prescription rate of APP significantly increased from 18.4 % in 2006 to 44.9 % in 2021. Compared with AMT, APP was associated with more clozapine use, more LAI use, higher doses of antipsychotics, and an increased risk of rehospitalization. In addition, the prescription of APP continued to increase during the study period. Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antipsychotic monotherapy; Antipsychotic polypharmacy; Chlorpromazine equivalent; Rehospitalization; Schizophrenia |
| المشرفين على المادة: | 0 (Antipsychotic Agents) J60AR2IKIC (Clozapine) |
| تواريخ الأحداث: | Date Created: 20231101 Date Completed: 20231206 Latest Revision: 20231206 |
| رمز التحديث: | 20231206 |
| DOI: | 10.1016/j.psychres.2023.115575 |
| PMID: | 37913621 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1872-7123 |
|---|---|
| DOI: | 10.1016/j.psychres.2023.115575 |