دورية أكاديمية
أعرض في EDS

Casein-assisted exfoliation of tungsten disulfide nanosheets for biomedical applications.

التفاصيل البيبلوغرافية
العنوان: Casein-assisted exfoliation of tungsten disulfide nanosheets for biomedical applications.
المؤلفون: Dalavi PA; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India., Prabhu A; Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India., M S; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India., Murugan SS; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India., Jayachandran V; Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India. Electronic address: venkatjchem@gmail.com.
المصدر: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2023 Dec; Vol. 232, pp. 113595. Date of Electronic Publication: 2023 Oct 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, c1993-
مواضيع طبية MeSH: Caseins* , Sulfides*, Bone Regeneration ; Alginates/pharmacology
مستخلص: Our regular life can be more challenging by bone abnormalities. Bone tissue engineering is used for repairing, regenerating, or replacing bone tissue that has been injured or infected. It is effective in overcoming the drawbacks of conventional bone grafting methods like autograft and allograft by enhancing the effectiveness of bone regeneration. Recent discoveries have shown that the exfoliation of transition metal dichalcogenides (TMDs) with protein is in great demand for bone tissue engineering applications. WS 2 nanosheets were developed using casein and subsequently characterized with different analytical techniques. Strong absorption peaks were observed in the UV-visible spectra at 520 nm and 630 nm. Alginate and alginate-casein WS 2 microspheres were developed. Stereomicroscopic images of the microspheres are spherical in shape and have an average diameter of around 0.8 ± 0.2 mm. The alginate-casein WS 2 microspheres show higher content of water absorption and retention properties than only alginate-containing microspheres. The apatite formation in the simulated bodily fluid solution was facilitated more effectively by the alginate-casein-WS 2 microspheres. Additionally, alginate-casein-WS 2 microspheres have a compressive strength is 58.01 ± 4 MPa. Finally, in vitro cell interaction studies reveals that both the microspheres are biocompatible with the C3H10T1/2 cells, and alginate-casein-WS 2 -based microspheres promote cell growth more significantly. Alginate-casein-WS 2 microspheres promote alkaline phosphatase activity, and mineralization process. Additionally, alginate-casein-WS 2 -based microspheres exponentially enhance the genes for ALP, BMP-2, OCN, and Collage type-1. The produced alginate-casein-WS 2 microspheres could be a suitable synthetic graft for a bone transplant replacement.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this research article.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Bone regeneration; Casein; Liquid exfoliation; Microspheres; Tungsten disulfide
المشرفين على المادة: 0 (tungsten sulfide)
0 (Caseins)
0 (Sulfides)
0 (Alginates)
تواريخ الأحداث: Date Created: 20231101 Date Completed: 20231127 Latest Revision: 20231127
رمز التحديث: 20240628
DOI: 10.1016/j.colsurfb.2023.113595
PMID: 37913705
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4367
DOI:10.1016/j.colsurfb.2023.113595