دورية أكاديمية
The Efficacy of Budesonide as Intrapolyp Injection Agent in the Management of Type 2 CRSwNP.
| العنوان: | The Efficacy of Budesonide as Intrapolyp Injection Agent in the Management of Type 2 CRSwNP. |
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| المؤلفون: | Elzayat S; Otorhinolaryngology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt., Lasheen H; Otorhinolaryngology Department, Faculty of Medicine, Cairo University, Giza, Egypt., Gehad I; Otorhinolaryngology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt., El-Deeb ME; Otorhinolaryngology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt., Soltan I; Otorhinolaryngology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt., Aouf MM; Otorhinolaryngology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt., Elgendy A; Otorhinolaryngology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt. |
| المصدر: | The Laryngoscope [Laryngoscope] 2024 May; Vol. 134 (5), pp. 2085-2092. Date of Electronic Publication: 2023 Nov 02. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8607378 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-4995 (Electronic) Linking ISSN: 0023852X NLM ISO Abbreviation: Laryngoscope Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009- >: Philadelphia, PA : Wiley-Blackwell Original Publication: St. Louis, Mo. : [s.n., 1896- |
| مواضيع طبية MeSH: | Nasal Polyps*/complications , Nasal Polyps*/drug therapy , Rhinitis*/complications , Rhinitis*/drug therapy , Rhinitis*/chemically induced, Humans ; Budesonide ; Chronic Disease ; Prednisolone ; Prospective Studies ; Steroids/adverse effects |
| مستخلص: | Objectives: To assess the efficacy and safety of budesonide as an intrapolyp injection in chronic rhinosinusitis with nasal polyps (CRSwNP) in comparison to control and systemic steroids. Method: In a prospective double-blinded controlled randomized clinical trial, 150 patients with CRSwNP were divided into 3 groups in a ratio 1:1:1 where group (A) was given oral prednisolone 1 mg/kg tapered daily for 2 weeks, group (B) was given budesonide intrapolyp injection weekly for 5 consecutive weeks, and group (C) was given intrapolyp injection with saline as the control group. Patients were assessed upon Sinonasal Outcome Test (SNOT-22) score, Total Nasal Polyp score (TNPS), Serum IgE, absolute eosinophilic count, and morning cortisol level before treatment, 1 week and 6 months after completing their treatment protocol. Results: SNOT 22 score improved significantly in all groups compared to those at baseline. Reduction in the oral and injection groups was much greater than the control group (P Conclusion: Intrapolyp steroid injection is considered a safe and effective method in nasal polyposis with limited side effects in comparison to systemic steroids. Using Budesonide as an agent for intrapolyp injection appears to be promising. It's advisable in patients with multiple relapses or high-risk patients to avoid repeated courses of oral steroids. Level of Evidence: 2 Laryngoscope, 134:2085-2092, 2024. (© 2023 The American Laryngological, Rhinological and Otological Society, Inc.) |
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| فهرسة مساهمة: | Keywords: Budesonide; chronic rhinosinusitis with nasal polyps; nasal polyps; oral steroid; prednisone |
| المشرفين على المادة: | 51333-22-3 (Budesonide) 9PHQ9Y1OLM (Prednisolone) 0 (Steroids) |
| تواريخ الأحداث: | Date Created: 20231102 Date Completed: 20240411 Latest Revision: 20240425 |
| رمز التحديث: | 20240426 |
| DOI: | 10.1002/lary.31137 |
| PMID: | 37916779 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-4995 |
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| DOI: | 10.1002/lary.31137 |