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New emerging targets in osteosarcoma therapy: PTEN and PI3K/Akt crosstalk in carcinogenesis.

التفاصيل البيبلوغرافية
العنوان: New emerging targets in osteosarcoma therapy: PTEN and PI3K/Akt crosstalk in carcinogenesis.
المؤلفون: Sadrkhanloo M; Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Paskeh MDA; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Hashemi M; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Raesi R; Department of Health Services Management, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical-Surgical Nursing, Mashhad University of Medical Sciences, Mashhad, Iran., Bahonar A; Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Nakhaee Z; Medical School, Gonabad University of Medical Sciences, Gonabad, Iran., Entezari M; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Beig Goharrizi MAS; Faculty of Biotechnology, University of Tehran, Tehran, Iran., Salimimoghadam S; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Ren J; Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Nabavi N; Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, V6H3Z6 Vancouver, BC, Canada., Rashidi M; Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: dr.mohsenrashidi@yahoo.com., Dehkhoda F; Department of Orthopedics, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: dehkhoda@sbmu.ac.ir., Taheriazam A; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address: a.taheriazam@iautmu.ac.ir., Tan SC; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Hushmandi K; Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address: Houshmandi.kia7@ut.ac.ir.
المصدر: Pathology, research and practice [Pathol Res Pract] 2023 Nov; Vol. 251, pp. 154902. Date of Electronic Publication: 2023 Oct 21.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE
أسماء مطبوعة: Publication: Stuttgart : Gustav Fischer Verlag
Original Publication: Stuttgart, New York, Fischer.
مواضيع طبية MeSH: Bone Neoplasms*/drug therapy , Bone Neoplasms*/genetics , Bone Neoplasms*/metabolism , Osteosarcoma*/genetics, Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Cell Line, Tumor ; Carcinogenesis ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Cell Proliferation/genetics
مستخلص: Osteosarcoma (OS) is a malignant bone carcinoma that affects people in childhood and adulthood. The heterogeneous nature and chromosomal instability represent certain characteristics of OS cells. These cancer cells grow and migrate abnormally, making the prognosis undesirable for patients. Conventional and current treatments fail to completely eradicate tumor cells, so new therapeutics targeting genes may be considered. PI3K/Akt is a regulator of events such as growth, cell death, migration, and differentiation, and its expression changes during cancer progression. PTEN reduces PI3K/Akt expression, and its mutations and depletions have been reported in various tumors. Experimental evidence shows that there is upregulation of PI3K/Akt and downregulation of PTEN in OS. Increasing PTEN expression may suppress PI3K/Akt to minimize tumorigenesis. In addition, PI3K/Akt shows a positive association with growth, metastasis, EMT and metabolism of OS cells and inhibits apoptosis. Importantly, overexpression of PI3K/Akt causes drug resistance and radio-resistance and its level can be modulated by miRNAs, lncRNAs and circRNAs. Silencing PI3K/Akt by compounds and drugs can suppress OS. Here, we review in detail the function of the PTEN/PI3K/Akt in OS, revealing its biological function, function in tumor progression, resistance to therapy, and pharmacological significance.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
فهرسة مساهمة: Keywords: Gene therapy; Non-coding RNAs; Osteosarcoma; PI3K/Akt; PTEN; Resistant
المشرفين على المادة: EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
EC 3.1.3.67 (PTEN Phosphohydrolase)
EC 3.1.3.67 (PTEN protein, human)
تواريخ الأحداث: Date Created: 20231103 Date Completed: 20231113 Latest Revision: 20231129
رمز التحديث: 20240829
DOI: 10.1016/j.prp.2023.154902
PMID: 37922723
قاعدة البيانات: MEDLINE
الوصف
تدمد:1618-0631
DOI:10.1016/j.prp.2023.154902