دورية أكاديمية
The neuropeptidergic connectome of C. elegans.
| العنوان: | The neuropeptidergic connectome of C. elegans. |
|---|---|
| المؤلفون: | Ripoll-Sánchez L; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Psychiatry, Cambridge University, Cambridge, UK., Watteyne J; Department of Biology, KU Leuven, Leuven, Belgium., Sun H; Department of Biological Sciences/HHMI, Columbia University, New York, NY, USA; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Fernandez R; Department of Biological Sciences/HHMI, Columbia University, New York, NY, USA., Taylor SR; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Weinreb A; Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA., Bentley BL; Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK., Hammarlund M; Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA., Miller DM 3rd; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Hobert O; Department of Biological Sciences/HHMI, Columbia University, New York, NY, USA., Beets I; Department of Biology, KU Leuven, Leuven, Belgium., Vértes PE; Department of Psychiatry, Cambridge University, Cambridge, UK., Schafer WR; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Biology, KU Leuven, Leuven, Belgium. Electronic address: wschafer@mrc-lmb.cam.ac.uk. |
| المصدر: | Neuron [Neuron] 2023 Nov 15; Vol. 111 (22), pp. 3570-3589.e5. Date of Electronic Publication: 2023 Nov 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Connectome*, Animals ; Caenorhabditis elegans/physiology ; Neurons/physiology ; Gene Expression ; Synapses |
| مستخلص: | Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the neural basis of brain function. However, chemical synapses represent only one type of functionally important neuronal connection; in particular, extrasynaptic, "wireless" signaling by neuropeptides is widespread and plays essential roles in all nervous systems. By integrating single-cell anatomical and gene-expression datasets with biochemical analysis of receptor-ligand interactions, we have generated a draft connectome of neuropeptide signaling in the C. elegans nervous system. This network is characterized by high connection density, extended signaling cascades, autocrine foci, and a decentralized topology, with a large, highly interconnected core containing three constituent communities sharing similar patterns of input connectivity. Intriguingly, several key network hubs are little-studied neurons that appear specialized for peptidergic neuromodulation. We anticipate that the C. elegans neuropeptidergic connectome will serve as a prototype to understand how networks of neuromodulatory signaling are organized. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | BRC-1215-20014 United Kingdom DH_ Department of Health; WT103784MA United Kingdom WT_ Wellcome Trust; United States HHMI Howard Hughes Medical Institute; MC_U105185857 United Kingdom MRC_ Medical Research Council; R01 NS100547 United States NS NINDS NIH HHS; R01 NS110391 United States NS NINDS NIH HHS; United Kingdom WT_ Wellcome Trust; MC-A023-5PB91 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: C. elegans; connectomics; networks; neuromodulation; neuropeptides |
| سلسلة جزيئية: | figshare 10.6084/m9.figshare.c.6895870.v1 |
| تواريخ الأحداث: | Date Created: 20231107 Date Completed: 20231120 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC7615469 |
| DOI: | 10.1016/j.neuron.2023.09.043 |
| PMID: | 37935195 |
| قاعدة البيانات: | MEDLINE |
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