دورية أكاديمية
The transcriptional legacy of developmental stochasticity.
| العنوان: | The transcriptional legacy of developmental stochasticity. |
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| المؤلفون: | Ballouz S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.; School of Computer Science and Engineering, Faculty of Engineering, University of New South Wales Sydney, Sydney, NSW, Australia., Kawaguchi RK; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.; Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan., Pena MT; US Department of Health and Human Services, Health Resources and Services Administration, Healthcare System Bureau, National Hansen's Disease Program, Baton Rouge, LA, 70803, USA., Fischer S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.; Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, F-75015, France., Crow M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.; Genentech, Inc., South San Francisco, CA, USA., French L; Physiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Knight FM; University of the Ozarks, Clarksville, AR, 72830, USA., Adams LB; US Department of Health and Human Services, Health Resources and Services Administration, Healthcare System Bureau, National Hansen's Disease Program, Baton Rouge, LA, 70803, USA., Gillis J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA. jesse.gillis@utoronto.ca.; Physiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada. jesse.gillis@utoronto.ca. |
| المصدر: | Nature communications [Nat Commun] 2023 Nov 09; Vol. 14 (1), pp. 7226. Date of Electronic Publication: 2023 Nov 09. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Armadillos*/physiology, Humans ; Animals ; Phenotype ; Alleles ; Penetrance |
| مستخلص: | Genetic and environmental variation are key contributors during organism development, but the influence of minor perturbations or noise is difficult to assess. This study focuses on the stochastic variation in allele-specific expression that persists through cell divisions in the nine-banded armadillo (Dasypus novemcinctus). We investigated the blood transcriptome of five wild monozygotic quadruplets over time to explore the influence of developmental stochasticity on gene expression. We identify an enduring signal of autosomal allelic variability that distinguishes individuals within a quadruplet despite their genetic similarity. This stochastic allelic variation, akin to X-inactivation but broader, provides insight into non-genetic influences on phenotype. The presence of stochastically canalized allelic signatures represents a novel axis for characterizing organismal variability, complementing traditional approaches based on genetic and environmental factors. We also developed a model to explain the inconsistent penetrance associated with these stochastically canalized allelic expressions. By elucidating mechanisms underlying the persistence of allele-specific expression, we enhance understanding of development's role in shaping organismal diversity. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | R01 LM012736 United States LM NLM NIH HHS; R01 MH113005 United States MH NIMH NIH HHS; L30 AA015006 United States AA NIAAA NIH HHS |
| تواريخ الأحداث: | Date Created: 20231108 Date Completed: 20231110 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC10632366 |
| DOI: | 10.1038/s41467-023-43024-5 |
| PMID: | 37940702 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-43024-5 |