دورية أكاديمية
أعرض في EDS

From Fish Physiology to Human Disease: The Discovery of the NCC, NKCC2, and the Cation-Coupled Chloride Cotransporters.

التفاصيل البيبلوغرافية
العنوان: From Fish Physiology to Human Disease: The Discovery of the NCC, NKCC2, and the Cation-Coupled Chloride Cotransporters.
المؤلفون: Gamba G; Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico City, Mexico.
المصدر: Kidney360 [Kidney360] 2024 Jan 01; Vol. 5 (1), pp. 133-141. Date of Electronic Publication: 2023 Nov 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 101766381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2641-7650 (Electronic) Linking ISSN: 26417650 NLM ISO Abbreviation: Kidney360 Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [Hagerstown, MD] : Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology
Original Publication: [Washington, DC] : American Society of Nephrology, [2020]-
مواضيع طبية MeSH: Chlorides*/metabolism , Sodium-Potassium-Chloride Symporters*/genetics , Sodium-Potassium-Chloride Symporters*/metabolism, Animals ; Humans ; Cations/metabolism ; Diuretics/metabolism ; Kidney Tubules, Distal/metabolism ; Sodium/metabolism ; Sodium Chloride/metabolism ; Solute Carrier Family 12, Member 3/metabolism ; Thiazides/metabolism ; Solute Carrier Family 12, Member 1
مستخلص: The renal Na-K-2Cl and Na-Cl cotransporters are the major salt reabsorption pathways in the thick ascending limb of Henle loop and the distal convoluted tubule, respectively. These transporters are the target of the loop and thiazide type diuretics extensively used in the world for the treatment of edematous states and arterial hypertension. The diuretics appeared in the market many years before the salt transport systems were discovered. The evolving of the knowledge and the cloning of the genes encoding the Na-K-2Cl and Na-Cl cotransporters were possible thanks to the study of marine species. This work presents the history of how we came to know the mechanisms for the loop and thiazide type diuretics actions, the use of marine species in the cloning process of these cotransporters and therefore in the whole solute carrier cotransproters 12 (SLC12) family of electroneutral cation chloride cotransporters, and the disease associated with each member of the family.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology.)
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المشرفين على المادة: 0 (Cations)
0 (Chlorides)
0 (Diuretics)
9NEZ333N27 (Sodium)
451W47IQ8X (Sodium Chloride)
0 (Sodium-Potassium-Chloride Symporters)
0 (Solute Carrier Family 12, Member 3)
0 (Thiazides)
0 (SLC12A3 protein, human)
0 (SLC12A1 protein, human)
0 (Solute Carrier Family 12, Member 1)
تواريخ الأحداث: Date Created: 20231116 Date Completed: 20240214 Latest Revision: 20240807
رمز التحديث: 20240807
مُعرف محوري في PubMed: PMC10833596
DOI: 10.34067/KID.0000000000000307
PMID: 37968800
قاعدة البيانات: MEDLINE
الوصف
تدمد:2641-7650
DOI:10.34067/KID.0000000000000307