دورية أكاديمية
Sex differences in the impact of social status on social reward and associated mesolimbic activation.
| العنوان: | Sex differences in the impact of social status on social reward and associated mesolimbic activation. |
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| المؤلفون: | Cross EA; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA 30303, United States., Huhman KL; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA 30303, United States., Albers HE; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA 30303, United States. Electronic address: biohea@gsu.edu. |
| المصدر: | Physiology & behavior [Physiol Behav] 2024 Jan 01; Vol. 273, pp. 114410. Date of Electronic Publication: 2023 Nov 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York NY : Elsevier Science Original Publication: Oxford, Eng., Long Island City, Pergamon Press. |
| مواضيع طبية MeSH: | Sex Characteristics* , Social Status*, Cricetinae ; Animals ; Male ; Female ; Humans ; Reward ; Mesocricetus ; Nucleus Accumbens/physiology ; Ventral Tegmental Area/physiology |
| مستخلص: | Social stress plays an important role in the etiology of many neuropsychiatric disorders and can lead to a variety of behavioral deficits such as social withdrawal. One way that social stress may contribute to psychiatric disorders is by reducing social motivation and the rewarding properties of social interactions. We investigated the impact of social stress on social reward in the context of winning versus losing agonistic encounters in Syrian hamsters (Mesocricetus auratus). First, we tested the hypothesis that social stress resulting from either stable low, or subordinate, social status or from social defeat reduces the rewarding properties of social interactions. Using an Operant Social Preference (OSP) task to measure social reward/motivation, we found that both subordinate and socially defeated males made significantly fewer entries into chambers containing novel, same-sex conspecifics compared to males who were dominant (i.e., stably won the agonistic encounters). In females, however, there were no differences in social entries between winners and losers. In a second experiment, we found more activation of the mesolimbic dopamine system (MDS) as assessed with cFos immunohistochemistry in the lateral ventral tegmental area (lVTA) and the nucleus accumbens (NAc) shell of male winners compared to losers. In females, however, there were no differences in activation in the lVTA between winners and losers. Surprisingly, however, winning females displayed significantly more activation in the NAc shell as compared to losing females, despite the lack of behavioral differences. Thus, behavioral and histological data suggest that there are sex differences in the impact of social status on social reward and associated mesolimbic activation. Competing Interests: Declaration of Competing Interest The authors have nothing to disclose. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | R01 MH122622 United States MH NIMH NIH HHS |
| فهرسة مساهمة: | Keywords: Nucleus accumbens; Social reward; Social status; Ventral tegmental area |
| تواريخ الأحداث: | Date Created: 20231117 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| DOI: | 10.1016/j.physbeh.2023.114410 |
| PMID: | 37977252 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-507X |
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| DOI: | 10.1016/j.physbeh.2023.114410 |