دورية أكاديمية
Effects of MAP4K inhibition on neurite outgrowth.
العنوان: | Effects of MAP4K inhibition on neurite outgrowth. |
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المؤلفون: | Lasham DJ; Departments of Psychiatry, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan., Arta RK; Departments of Psychiatry, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan., Hadi AF; Departments of Psychiatry, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan., Egawa J; Departments of Psychiatry, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan. jeg5414@med.niigata-u.ac.jp.; Departments of Neurochemistry and Molecular Cell Biology, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan. jeg5414@med.niigata-u.ac.jp., Lemmon VP; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA.; Institute for Data Science and Computing, University of Miami Miller School of Medicine, Miami, FL, USA., Takasugi T; Departments of Neurochemistry and Molecular Cell Biology, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan., Igarashi M; Departments of Neurochemistry and Molecular Cell Biology, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan. tarokaja@med.niigata-u.ac.jp., Someya T; Departments of Psychiatry, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, 757 Asahimachi Dori-Ichibancho, Chuo-Ku, Niigata, 951-8510, Japan. |
المصدر: | Molecular brain [Mol Brain] 2023 Nov 18; Vol. 16 (1), pp. 79. Date of Electronic Publication: 2023 Nov 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606 (Electronic) Linking ISSN: 17566606 NLM ISO Abbreviation: Mol Brain Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central |
مواضيع طبية MeSH: | Neurons*/metabolism , Neurites*/metabolism, Humans ; Signal Transduction ; Phosphorylation ; Neuronal Outgrowth |
مستخلص: | Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in neuronal development. Here, we considered mitogen-activated protein kinase kinase kinase kinases (MAP4Ks), related to as candidate regulators of neurite outgrowth and synaptogenesis, by examining the effects of a selective MAP4K inhibitor PF06260933. PF06260933 treatments of the cultured neurons reduced neurite lengths, not the number of synapses, and phosphorylation of GAP43 and JNK, relative to the control. These results suggest that MAP4Ks are physiologically involved in normal neuronal development and that the resultant impaired neurite outgrowth by diminished MAP4Ks' activity, is related to psychiatric disorders. (© 2023. The Author(s).) |
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معلومات مُعتمدة: | #20H03597 Japan Society for the Promotion of Science; #21K07496 Japan Society for the Promotion of Science; #18H04013 Japan Society for the Promotion of Science; #21gm1210007s0103 Japan Agency for Medical Research and Development; #22gm1210007s0104 Japan Agency for Medical Research and Development; #23gm1210007s0105 Japan Agency for Medical Research and Development |
فهرسة مساهمة: | Keywords: High content screening; Mitogen-activated protein kinase kinase kinase kinases (MAP4Ks); Neurite growth; Psychiatric disorders; Synaptogenesis |
تواريخ الأحداث: | Date Created: 20231119 Date Completed: 20231120 Latest Revision: 20231121 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10656890 |
DOI: | 10.1186/s13041-023-01066-2 |
PMID: | 37980537 |
قاعدة البيانات: | MEDLINE |
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