دورية أكاديمية
Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2 .
| العنوان: | Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2 . |
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| المؤلفون: | Peng J; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China., Zhang Q; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China., Lin F; Department of Oncology, Guangdong Provincial Hospital of Integrated Traditional Chinese & Western Medicine, Affiliated Nanhai Hospital of Traditional Chinese Medicine of Jinan University, Foshan, Guangdong Province, 528200, China., Ke C; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China., Deng W; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China., Yang A; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China., Su X; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China. |
| المصدر: | Epigenomics [Epigenomics] 2023 Nov; Vol. 15 (21), pp. 1101-1119. Date of Electronic Publication: 2023 Nov 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Future Medicine Country of Publication: England NLM ID: 101519720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-192X (Electronic) Linking ISSN: 1750192X NLM ISO Abbreviation: Epigenomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Future Medicine, 2009- |
| مواضيع طبية MeSH: | Proto-Oncogene Proteins B-raf*/genetics , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/pathology, Humans ; DNA Methylation ; Epigenesis, Genetic ; Lymphatic Metastasis ; Mutation ; GluK2 Kainate Receptor |
| مستخلص: | Aim: Conservative treatment approaches for thyroid carcinoma (TC) patients with wild-type B-type Raf kinase ( BRAF ) pose risks of long-term recurrence. The association of DNA methylation with TC metastasis is unclear. Patients & methods: Here we analyzed data from 179 BRAF wild-type TC patients in the The Cancer Genome Atlas database, identifying significant metastasis-associated CpGs. A logistic regression model was developed and validated for discriminating lymphatic metastasis in BRAF wild-type TC. Results: The model showed high accuracy (AUC: 0.924 training set; 0.812 and 0.773 external cohorts). TAGLN , MRPL4 , CLDN10 and GRIK2 emerged as diagnostic markers. GRIK2 , downregulated due to promoter hypermethylation, acted as a TC suppressor. Conclusion: Our 5-CpG epigenetic signature effectively discriminates lymphatic metastasis in BRAF wild-type TC, highlighting GRIK2 's tumor-suppressive role influenced by promoter hypermethylation. |
| معلومات مُعتمدة: | 82072981, 82272649 National Natural Science Foundation of China; 2021A1515010083 Guangdong Basic and Applied Basic Research Foundation; 2019A1515010150 Natural Science Foundation of Guangdong Province |
| فهرسة مساهمة: | Keywords: BRAF wild-type; DNA methylation marker; GRIK2; epigenetic signature; metastasis; thyroid carcinoma |
| المشرفين على المادة: | EC 2.7.11.1 (BRAF protein, human) EC 2.7.11.1 (Proto-Oncogene Proteins B-raf) |
| تواريخ الأحداث: | Date Created: 20231122 Date Completed: 20231204 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2217/epi-2023-0334 |
| PMID: | 37990886 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1750-192X |
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| DOI: | 10.2217/epi-2023-0334 |