دورية أكاديمية
Sex differences in radiation research.
| العنوان: | Sex differences in radiation research. |
|---|---|
| المؤلفون: | Taliaferro LP; Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Radiation and Nuclear Countermeasures Program (RNCP), Rockville, MD, USA., Agarwal RK; Office of Research on Women's Health (ORWH), Office of the Director, NIH, Rockville, MD, USA., Coleman CN; Radiation Research Program Division of Cancer Treatment and Diagnosis, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI) and Administration for Strategic Preparedness and Response (ASPR), U.S. Department of Health and Human Services (HHS), Washington, DC, USA., DiCarlo AL; Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Radiation and Nuclear Countermeasures Program (RNCP), Rockville, MD, USA., Hofmeyer KA; Radiological and Nuclear Countermeasures Branch, Biomedical Advanced Research and Development Authority (BARDA), ASPR, HHS, Washington, DC, USA., Loelius SG; Radiological and Nuclear Countermeasures Branch, Biomedical Advanced Research and Development Authority (BARDA), ASPR, HHS, Washington, DC, USA., Molinar-Inglis O; Previously RNCP, DAIT, NIAID, NIH; now Antivirals and Antitoxins Program, Division of CBRN Countermeasures, BARDA, ASPR, HHS, Washington, DC, USA., Tedesco DC; Radiological and Nuclear Countermeasures Branch, Biomedical Advanced Research and Development Authority (BARDA), ASPR, HHS, Washington, DC, USA., Satyamitra MM; Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Radiation and Nuclear Countermeasures Program (RNCP), Rockville, MD, USA. |
| المصدر: | International journal of radiation biology [Int J Radiat Biol] 2024; Vol. 100 (3), pp. 466-485. Date of Electronic Publication: 2023 Nov 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 8809243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-3095 (Electronic) Linking ISSN: 09553002 NLM ISO Abbreviation: Int J Radiat Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London ; New York : Taylor & Francis, [c1988- |
| مواضيع طبية MeSH: | Acute Radiation Syndrome* , Biomedical Research*, Male ; Animals ; Female ; Humans ; United States ; Sex Characteristics ; Research Design |
| مستخلص: | Purpose: The Sex Differences in Radiation Research workshop addressed the role of sex as a confounder in radiation research and its implication in real-world radiological and nuclear applications. Methods: In April 2022, HHS-wide partners from the Radiation and Nuclear Countermeasures Program, the Office of Research on Women's Health National Institutes of Health Office of Women's Health, U.S. Food and Drug Administration, and the Radiological and Nuclear Countermeasures Branch at the Biomedical Advanced Research and Development Authority conducted a workshop to address the scientific implication and knowledge gaps in understanding sex in basic and translational research. The goals of this workshop were to examine sex differences in 1. Radiation animal models and understand how these may affect radiation medical countermeasure development; 2. Biodosimetry and/or biomarkers used to assess acute radiation syndrome, delayed effects of acute radiation exposure, and/or predict major organ morbidities; 3. medical research that lacks representation from both sexes. In addition, regulatory policies that influence inclusion of women in research, and the gaps that exist in drug development and device clearance were discussed. Finally, real-world sex differences in human health scenarios were also considered. Results: This report provides an overview of the two-day workshop, and open discussion among academic investigators, industry researchers, and U.S. government representatives. Conclusions: This meeting highlighted that current study designs lack the power to determine statistical significance based on sex, and much is unknown about the underlying factors that contribute to these differences. Investigators should accommodate both sexes in all stages of research to ensure that the outcome is robust, reproducible, and accurate, and will benefit public health. |
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| معلومات مُعتمدة: | Z99 AI999999 United States ImNIH Intramural NIH HHS |
| فهرسة مساهمة: | Keywords: Women’s health; biodosimetry; medical countermeasures; radiation; sex differences |
| تواريخ الأحداث: | Date Created: 20231122 Date Completed: 20240229 Latest Revision: 20240309 |
| رمز التحديث: | 20240309 |
| مُعرف محوري في PubMed: | PMC10922591 |
| DOI: | 10.1080/09553002.2023.2283089 |
| PMID: | 37991728 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1362-3095 |
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| DOI: | 10.1080/09553002.2023.2283089 |