Pregabalin alters reproductive performance in male mice and causes congenital anomalies in offspring.

التفاصيل البيبلوغرافية
العنوان:	Pregabalin alters reproductive performance in male mice and causes congenital anomalies in offspring.
المؤلفون:	Mestre VF; Graduate Program in Health Sciences, State University of Londrina, Londrina, Paraná, Brazil; and Department of General Biology, Center for Biological Sciences, State University of Londrina, Londrina, Brazil., Martins CCN; Department of General Biology, Center for Biological Sciences, State University of Londrina, Londrina, Brazil., Brito LV; Department of General Biology, Center for Biological Sciences, State University of Londrina, Londrina, Brazil., Zeffa AC; Graduate Program in Health Sciences, State University of Londrina, Londrina, Paraná, Brazil; and Department of General Biology, Center for Biological Sciences, State University of Londrina, Londrina, Brazil., Sestário CS; Graduate Program in Health Sciences, State University of Londrina, Londrina, Paraná, Brazil; and Department of General Biology, Center for Biological Sciences, State University of Londrina, Londrina, Brazil., Salles MJS; Department of General Biology, Center for Biological Sciences, State University of Londrina, Londrina, Brazil.
المصدر:	Reproduction, fertility, and development [Reprod Fertil Dev] 2023 Nov; Vol. 35 (18), pp. 750-759.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Commonwealth Scientific and Industrial Research Organisation Country of Publication: Australia NLM ID: 8907465 Publication Model: Print Cited Medium: Internet ISSN: 1031-3613 (Print) Linking ISSN: 10313613 NLM ISO Abbreviation: Reprod Fertil Dev Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: East Melbourne, Vic., Australia : Commonwealth Scientific and Industrial Research Organisation, c1989-
مواضيع طبية MeSH:	Placenta* , Teratogenesis*, Male ; Mice ; Female ; Animals ; Pregnancy ; Pregabalin/pharmacology ; Analgesics/adverse effects ; Reproduction ; Water
مستخلص:	Context: Pregabalin is an anticonvulsant drug with analgesic activity for the treatment of neuropathic pain. Aims: To valuate the toxicity of pregabalin in reproductive parameters, spermatogenesis, and teratogenicity in the offspring of mice. Methods: Twenty male mice were randomly distributed into two groups: PGB group and group C (n =10 per group). The animals in the PGB group received, via gavage, 200mg/kg of pregabalin diluted in distilled water daily, for a period of 45days. Group C received distilled water under the same experimental design. Key Results: In the paternal parameters of the PGB group, there was a significant increase in the size of the testicles, morphological alterations in the spermatozoa, a decrease in the Johnsen score, an increase in the Leydig cells, and a decrease in the serum level of testosterone. In the intrauterine development parameters of females mated with males from the PGB group, a significant decrease in placental weight, weight and length of fetuses, and fetal viability rate was observed. There was a significant increase in the number of resorptions and post-implantation losses. The significant anomalies observed in the offspring were alteration in the size of the kidneys, absent metacarpals and phalanges, alteration in the sternum, and supernumerary thoracic vertebrae. Conclusion: Results suggest that pregabalin had toxic effects on the reproductive function of male mice and teratogenic potential. Implications: The findings of this study may provide new hypotheses, taking into account the risk-benefit ratio for male reproduction and offspring health.
المشرفين على المادة:	55JG375S6M (Pregabalin) 0 (Analgesics) 059QF0KO0R (Water)
تواريخ الأحداث:	Date Created: 20231123 Date Completed: 20231129 Latest Revision: 20231129
رمز التحديث:	20231130
DOI:	10.1071/RD22287
PMID:	37995339
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1031-3613
DOI:	10.1071/RD22287