دورية أكاديمية
A comparative study on the quality of in vivo labeled red blood cell radionuclide ventriculography images employing different freeze-dried reagents.
| العنوان: | A comparative study on the quality of in vivo labeled red blood cell radionuclide ventriculography images employing different freeze-dried reagents. |
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| المؤلفون: | Pujatti PB; Nuclear Medicine Service, Cancer Hospital I, National Cancer Institute (INCA),Health Ministry, Rio de Janeiro, Brazil., Dos Santos JPG, Gomes ML, Cardoso MAS, Guimarães TT, Felix RCM |
| المصدر: | Nuclear medicine communications [Nucl Med Commun] 2024 Feb 01; Vol. 45 (2), pp. 155-160. Date of Electronic Publication: 2023 Nov 28. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Lippincott Williams & Wilkins Original Publication: London : Chapman and Hall in association with the British Nuclear Medicine Society, c1980- |
| مواضيع طبية MeSH: | Technetium* , Radiopharmaceuticals*, Humans ; Cross-Sectional Studies ; Retrospective Studies ; Radionuclide Ventriculography ; Pentetic Acid ; Erythrocytes |
| مستخلص: | Radionuclide ventriculography or Multi Gated Acquisition (MUGA) employing [ 99m Tc]Technetium red blood cell (RBC) labeling is considered the gold standard for cardiotoxicity assessments in cancer patients undergoing chemotherapy. This in-vivo RBC labeling technique involves the reduction of [ 99m Tc]Technetium by the stannous chloride present in freeze-dried reagent kits, with the pyrophosphate kit (PYP) being the most employed for this purpose. The literature, however, describes diethylenetriaminepentaacetic acid (DTPA) as an alternative to PYP, although a lack of comparative data from MUGA images between both reagents is noted. A retrospective cross-sectional observational study was conducted at the Brazilian National Cancer Institute Nuclear Medicine Service concerning 80 randomized MUGA images, 20 obtained employing DTPA between 2020 and 2023 and 60 obtained employing PYP between 2017 and 2020, applying the mean count per pixel (ct/pixel) and heart background (C/F) ratios as quality image indicators. Although the heart ct/pixel ratio was statistically lower in the DTPA images compared with PYP ( P = 0.02), the C/F ratio was statistically similar when comparing both radiopharmaceuticals ( P = 0.697). A semi-quantitative analysis of MUGA images obtained with DTPA and PYP indicates similar image quality, supporting the use of DTPA as an alternative to PYP without compromising diagnostic interpretations. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
| References: | Bauer R, Haluszczynski I, Langhammer H, Bachmann W. In vivo/in vitro labeling of red blood cells with 99mTc. Eur J Nucl Med 1983; 8:218–222. Sreenivasan J, Hooda U, Ranjan P, Jain D. Nuclear imaging for the assessment of cardiotoxicity from chemotherapeutic agents in oncologic disease. Curr Cardiol Rep 2021; 23:65. Sachpekidis C, Sachpekidis V, Moralidis E, Arsos G. Equilibrium radionuclide ventriculography: still a clinically useful method for the assessment of cardiac function? Hell J Nucl Med 2018; 21:213–220. Grady E. Gastrointestinal bleeding scintigraphy in the early 21st century. J Nucl Med 2016; 57:252–259. Popescu HI, Lessem J, Erjavec M, Fiiger GF. In vivo labelling of RBC with 99mTc for blood pool imaging using different stannous radiopharmaceuticals. Eur J Nucl Med 1984; 9:295–299. Ouyang J, El Fakhri G. Quantitative nuclear medicine. In Nuclear Medicine Physics. Chapter 17. IAEA: N. 2014. Callahan RJ, Froelich JW, McKusick KA, Leppo J, Strauss HW. A Modified method for the in vivo labeling of red blood cells withTc-99m: concise communication. J NucI Med 1982; 23:315–318. Hambye AE, Verbeke KA, Vandermeiren RP, Joosens EJ, Verbruggen AM, De Roo MJ. Comparison of modified technetium-99m albumin and technetium-99m red blood cells for equilibrium ventriculography. J Nuc Med 1997; 38:1521–1528. Ahmad I, Sajjad A, Mehmood Z, Bin Asad MH, Rahim MK, Hussain MS, et al. Preparation and radiochemical control of 99mtc labeled blood pool agent for in vivo labelling of the red blood cells. Acta Pol Pharm 2014; 71:245–248. |
| المشرفين على المادة: | 7440-26-8 (Technetium) 0 (Radiopharmaceuticals) 4E862E7GRQ (diphosphoric acid) 7A314HQM0I (Pentetic Acid) |
| تواريخ الأحداث: | Date Created: 20231127 Date Completed: 20240111 Latest Revision: 20240111 |
| رمز التحديث: | 20240111 |
| DOI: | 10.1097/MNM.0000000000001794 |
| PMID: | 38010319 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5628 |
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| DOI: | 10.1097/MNM.0000000000001794 |