دورية أكاديمية
Correlates of Circulating Osteoprotegerin in Women with a Pathogenic or Likely Pathogenic Variant in the BRCA1 Gene.
| العنوان: | Correlates of Circulating Osteoprotegerin in Women with a Pathogenic or Likely Pathogenic Variant in the BRCA1 Gene. |
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| المؤلفون: | Park SS; Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.; Women's College Research Institute, Women's College Hospital, Toronto, Canada., Zaman T; Women's College Research Institute, Women's College Hospital, Toronto, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Kim SJ; Women's College Research Institute, Women's College Hospital, Toronto, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada., Brooks JD; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Wong AKO; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.; Joint Department of Medical Imaging, University Health Network, Toronto, Canada.; Osteoporosis Program, Schroeder Arthritis Institute, University Health Network, Toronto, Canada., Lubiński J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.; Read-Gene S.A., Grzepnica, Poland., Narod SA; Women's College Research Institute, Women's College Hospital, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Salmena L; Women's College Research Institute, Women's College Hospital, Toronto, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Kotsopoulos J; Women's College Research Institute, Women's College Hospital, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. |
| المصدر: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2024 Feb 06; Vol. 33 (2), pp. 298-305. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print Cited Medium: Internet ISSN: 1538-7755 (Electronic) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research, c1991- |
| مواضيع طبية MeSH: | Genes, BRCA1* , Osteoprotegerin*/genetics, Adult ; Female ; Humans ; BRCA1 Protein/genetics ; Longitudinal Studies ; Smoking |
| مستخلص: | Background: Lower levels of osteoprotegerin (OPG), the decoy receptor for receptor activator of NFκB (RANK)-ligand, have been reported among women with a BRCA1 mutation, suggesting OPG may be marker of cancer risk. Whether various reproductive, hormonal, or lifestyle factors impact OPG levels in these women is unknown. Methods: BRCA1 mutation carriers enrolled in a longitudinal study, no history of cancer, and a serum sample for OPG quantification, were included. Exposure information was collected through self-reported questionnaire at study enrollment and every 2 years thereafter. Serum OPG levels (pg/mL) were measured using an ELISA, and generalized linear models were used to assess the associations between reproductive, hormonal, and lifestyle exposures at the time of blood collection with serum OPG. Adjusted means were estimated using the fully adjusted model. Results: A total of 701 women with a median age at blood collection of 39.0 years (18.0-82.0) were included. Older age (Spearman r = 0.24; P < 0.001) and current versus never smoking (98.82 vs. 86.24 pg/mL; Pcat < 0.001) were associated with significantly higher OPG, whereas ever versus never coffee consumption was associated with significantly lower OPG (85.92 vs. 94.05 pg/mL; Pcat = 0.03). There were no other significant associations for other exposures (P ≥ 0.06). The evaluated factors accounted for 7.5% of the variability in OPG. Conclusions: OPG is minimally influenced by hormonal and lifestyle factors among BRCA1 mutation carriers. Impact: These findings suggest that circulating OPG levels are not impacted by non-genetic factors in high-risk women. (©2023 American Association for Cancer Research.) |
| معلومات مُعتمدة: | Canadian Institutes of Health Research (IRSC); 705459 Canadian Cancer Society (CCS); Peter Gilgan Foundation (The Peter Gilgan Foundation); Canada Research Chairs (Chaires de recherche du Canada) |
| المشرفين على المادة: | 0 (BRCA1 Protein) 0 (BRCA1 protein, human) 0 (Osteoprotegerin) 0 (TNFRSF11B protein, human) |
| تواريخ الأحداث: | Date Created: 20231128 Date Completed: 20240213 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| DOI: | 10.1158/1055-9965.EPI-23-0577 |
| PMID: | 38015775 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1538-7755 |
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| DOI: | 10.1158/1055-9965.EPI-23-0577 |