دورية أكاديمية
Cognitive performance during senescence in untreated congenital isolated GH deficiency.
| العنوان: | Cognitive performance during senescence in untreated congenital isolated GH deficiency. |
|---|---|
| المؤلفون: | Batista VO; Division of Psychiatry, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Kellner M; Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany and Technical University of Munich, Munich, Germany., Salvatori R; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Lisboa W; Department of Psychology, Federal University of Sergipe, São Cristovão, Sergipe, Brazil., Faro A; Postgraduate Program in Psychology, Federal University of Sergipe, São Cristovão, Sergipe, Brazil., Santos LB; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Melo EV; Statistics division, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Oliveira-Santos AA; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Oliveira CRP; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Campos VC; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Barros-Oliveira CS; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Santos EG; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Santana NO; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Villar-Gouy KR; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Leal ÂC; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Amorim RS; Division of Geriatrics, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Oliveira Simões DA; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Aguiar-Oliveira MH; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil. |
| المصدر: | Endocrine connections [Endocr Connect] 2023 Dec 21; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 101598413 Publication Model: Electronic-Print Cited Medium: Print ISSN: 2049-3614 (Print) Linking ISSN: 20493614 NLM ISO Abbreviation: Endocr Connect Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol : BioScientifica |
| مستخلص: | Individuals with untreated isolated GH deficiency (IGHD) due to a mutation in the GHRH receptor gene from Itabaianinha Brazil have increased insulin sensitivity, normal life expectancy, and an extended health span, i.e. the period of life free from disabilities. We hypothesize that their prolonged health span is accompanied by a delayed cognitive decline in senescence. To test this hypothesis, we have administered the Literacy-Independent Cognitive Assessment (LICA) to 15 IGHD individuals aged over 50 years and 15 controls matched by age, sex, years of education, and percentage of illiteracy. All individuals were negative for HIV and syphilis serology, and there were no differences in serum levels of folate, vitamin B12 and TSH between the two groups, while free T4 was higher in the IGHD group. IGHD subjects had a higher total LICA score than controls, 215 (22.7) vs 204.2 (18.1), without reaching statistical significance. Scores of memory, visuoconstruction, language and calculation were similar between the two groups, with better attention (9.5 (1.4) vs 8.3 (1.1), P = 0.01) and executive function (38.3 (4.8) vs 35.1 (2.5), P = 0.03) scores in IGHD. MANCOVA revealed that group (but no age) had a significant effect on the LICA variables (partial eta squared of 0.455, power of 0.812, P = 0.02). This effect is verified on attention (partial eta squared 0.216, power of 0.749, P = 0.01) and executive function (partial eta squared 0.154, power of 0.570, P = 0.03. In conclusion, IGHD in senescence is associated with similar total cognitive performance but better attention and executive function than controls. |
| References: | J Clin Endocrinol Metab. 2014 Sep;99(9):3285-9. (PMID: 24926956) J Clin Endocrinol Metab. 1999 Mar;84(3):917-23. (PMID: 10084571) Vitam Horm. 2023;123:1-26. (PMID: 37717982) Rev Endocr Metab Disord. 2021 Mar;22(1):81-89. (PMID: 32935264) Brain Behav Immun. 2022 Mar;101:93-135. (PMID: 34973396) Exp Neurol. 2019 May;315:1-8. (PMID: 30695707) Brain Res Rev. 2007 Dec;56(2):384-402. (PMID: 17920690) J Clin Endocrinol Metab. 2010 Feb;95(2):714-21. (PMID: 19965916) JAMA. 2003 Mar 19;289(11):1371-3. (PMID: 12636453) Aging Cell. 2021 Jul;20(7):e13420. (PMID: 34118183) Neurosci Lett. 1987 Aug 31;79(3):251-6. (PMID: 3658217) Geriatr Gerontol Int. 2015 Sep;15(9):1118-26. (PMID: 25407304) Dement Neuropsychol. 2010 Jan-Mar;4(1):35-41. (PMID: 29213658) iScience. 2021 Oct 14;24(11):103275. (PMID: 34761193) J Clin Endocrinol Metab. 2012 Mar;97(3):1013-9. (PMID: 22170707) J Clin Endocrinol Metab. 1995 Dec;80(12):3585-90. (PMID: 8530603) Neurosci Res. 2019 Dec;149:1-13. (PMID: 30389571) Eur J Endocrinol. 2004 Feb;150(2):153-9. (PMID: 14763913) Arch Neurol. 2012 Nov;69(11):1420-9. (PMID: 22869065) Front Neuroendocrinol. 2000 Oct;21(4):330-48. (PMID: 11013068) Endocrine. 2021 May;72(2):349-355. (PMID: 33860882) Psychoneuroendocrinology. 2009 Jul;34(6):894-900. (PMID: 19181452) J Clin Endocrinol Metab. 1998 Sep;83(9):3184-9. (PMID: 9745423) Neurology. 2008 Nov 18;71(21):1702-8. (PMID: 19015485) Spine (Phila Pa 1976). 2000 Dec 15;25(24):3186-91. (PMID: 11124735) Nucl Med Commun. 2022 Mar 1;43(3):275-283. (PMID: 34816810) Psychoneuroendocrinology. 1998 Jan;23(1):45-55. (PMID: 9618751) Pharm Stat. 2018 May;17(3):214-230. (PMID: 29322632) Psychiatry Investig. 2015 Jul;12(3):341-8. (PMID: 26207127) J Clin Endocrinol Metab. 2013 Nov;98(11):E1710-5. (PMID: 24057284) Nat Rev Endocrinol. 2013 Jun;9(6):357-65. (PMID: 23629538) Int J Mol Sci. 2022 Jul 16;23(14):. (PMID: 35887196) Endocr Rev. 2019 Apr 1;40(2):575-601. (PMID: 30576428) Endocr Connect. 2016 Jan;5(1):41-6. (PMID: 26811426) Physiol Rev. 2016 Oct;96(4):1169-209. (PMID: 27489306) Endocrine. 2019 Jan;63(1):112-119. (PMID: 30251164) Endocr Connect. 2018 Aug 01;7(8):924-931. (PMID: 30300535) Int Psychogeriatr. 2011 May;23(4):593-601. (PMID: 20843392) Front Neurosci. 2019 Oct 18;13:1112. (PMID: 31680842) Eur J Endocrinol. 2005 Sep;153(3):379-87. (PMID: 16131600) Horm Res. 1996;45(1-2):23-9. (PMID: 8742114) Cell Mol Neurobiol. 2003 Feb;23(1):1-25. (PMID: 12701881) Psychoneuroendocrinology. 2004 Aug;29(7):839-50. (PMID: 15177699) J Alzheimers Dis. 2018;66(3):971-981. (PMID: 30372675) J Clin Endocrinol Metab. 2019 Jul 1;104(7):2777-2784. (PMID: 30860584) J Int Neuropsychol Soc. 2015 Sep;21(8):622-8. (PMID: 26272269) Rev Endocr Metab Disord. 2021 Mar;22(1):71-80. (PMID: 33001358) J Neurosci. 2017 Feb 15;37(7):1696-1707. (PMID: 28073935) Psychoneuroendocrinology. 2006 Jul;31(6):681-91. (PMID: 16621325) Proc Natl Acad Sci U S A. 1988 Jan;85(1):265-9. (PMID: 3422422) J Clin Endocrinol Metab. 2006 Mar;91(3):860-4. (PMID: 16394080) Eur J Endocrinol. 2017 Aug;177(2):R85-R97. (PMID: 28428227) |
| فهرسة مساهمة: | Keywords: GH; GHRH receptor; cognition; senescence |
| تواريخ الأحداث: | Date Created: 20231129 Latest Revision: 20240105 |
| رمز التحديث: | 20240105 |
| مُعرف محوري في PubMed: | PMC10762558 |
| DOI: | 10.1530/EC-23-0401 |
| PMID: | 38019109 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!