دورية أكاديمية
The pharmacokinetics of cisplatin in experimental regional chemotherapy.
| العنوان: | The pharmacokinetics of cisplatin in experimental regional chemotherapy. |
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| المؤلفون: | Wile AG, Kar R, Cohen RA, Jakowatz JG, Opfell RW |
| المصدر: | Cancer [Cancer] 1987 Feb 15; Vol. 59 (4), pp. 695-700. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print Cited Medium: Print ISSN: 0008-543X (Print) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005- >: Hoboken, NJ : Wiley Original Publication: New York [etc.] Published for the American Cancer Society by J. Wiley [etc.] |
| مواضيع طبية MeSH: | Cisplatin/*metabolism , Neoplasms, Experimental/*drug therapy, Animals ; Chemotherapy, Cancer, Regional Perfusion ; Cisplatin/administration & dosage ; Injections, Intra-Arterial ; Injections, Intravenous ; Methods ; Muscles/metabolism ; Neoplasms, Experimental/metabolism ; Rabbits ; Time Factors |
| مستخلص: | Cisplatin (DDP) is attractive for use in regional chemotherapy because of its tendency for protein binding. A study of regional chemotherapy was conducted in rabbits bearing the VX-2 carcinoma. Modes of therapy examined were intravenous (IV), intra-arterial (IA), IA with stopflow, IA with outflow occlusion, and isolation-perfusion (I-P). Each mode was evaluated by examining the pharmacokinetics of DDP in systemic and regional administration and measuring tissue concentrations of DDP. It was observed that the systemic exposure to DDP was significantly less for IA with outflow occlusion and I-P when compared to IV, IA, or IA with stopflow occlusion (P = 0.003). Tumor concentrations were highest with IA infusion with outflow occlusion (P = 0.002) and IA stopflow occlusion (P = 0.03). Tumor tissue concentrations were always higher than adjacent muscle DDP concentrations. The authors conclude that significant pharmacologic advantage can be demonstrated for certain modes of DDP administration in this rabbit model, and that these promising results should be followed by clinical trials. |
| المشرفين على المادة: | Q20Q21Q62J (Cisplatin) |
| تواريخ الأحداث: | Date Created: 19870215 Date Completed: 19870319 Latest Revision: 20190619 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/1097-0142(19870215)59:4<695::aid-cncr2820590406>3.0.co;2-g |
| PMID: | 3802029 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0008-543X |
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| DOI: | 10.1002/1097-0142(19870215)59:4<695::aid-cncr2820590406>3.0.co;2-g |