دورية أكاديمية
أعرض في EDS

Unveiling invisible farm-to-farm PRRSV-2 transmission links and routes through transmission tree and network analysis.

التفاصيل البيبلوغرافية
العنوان: Unveiling invisible farm-to-farm PRRSV-2 transmission links and routes through transmission tree and network analysis.
المؤلفون: Pamornchainavakul N; University of Minnesota Saint Paul Minnesota USA., Makau DN; University of Minnesota Saint Paul Minnesota USA., Paploski IAD; University of Minnesota Saint Paul Minnesota USA., Corzo CA; University of Minnesota Saint Paul Minnesota USA., VanderWaal K; University of Minnesota Saint Paul Minnesota USA.
المصدر: Evolutionary applications [Evol Appl] 2023 Sep 15; Vol. 16 (10), pp. 1721-1734. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Pub Country of Publication: England NLM ID: 101461828 Publication Model: eCollection Cited Medium: Print ISSN: 1752-4571 (Print) Linking ISSN: 17524571 NLM ISO Abbreviation: Evol Appl Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Blackwell Pub.
مستخلص: The United States (U.S.) swine industry has struggled to control porcine reproductive and respiratory syndrome (PRRS) for decades, yet the causative virus, PRRSV-2, continues to circulate and rapidly diverges into new variants. In the swine industry, the farm is typically the epidemiological unit for monitoring, prevention, and control; breaking transmission among farms is a critical step in containing disease spread. Despite this, our understanding of farm transmission still is inadequate, precluding the development of tailored control strategies. Therefore, our objective was to infer farm-to-farm transmission links, estimate farm-level transmissibility as defined by reproduction numbers ( R ), and identify associated risk factors for transmission using PRRSV-2 open reading frame 5 (ORF5) gene sequences, animal movement records, and other data from farms in a swine-dense region of the U.S. from 2014 to 2017. Timed phylogenetic and transmission tree analyses were performed on three sets of sequences ( n  = 206) from 144 farms that represented the three largest genetic variants of the virus in the study area. The length of inferred pig-to-pig infection chains that corresponded to pairs of farms connected via direct animal movement was used as a threshold value for identifying other feasible transmission links between farms; these links were then transformed into farm-to-farm transmission networks and calculated farm-level R -values. The median farm-level R was one (IQR = 1-2), whereas the R value of 28% of farms was more than one. Exponential random graph models were then used to evaluate the influence of farm attributes and/or farm relationships on the occurrence of farm-to-farm transmission links. These models showed that, even though most transmission events cannot be directly explained by animal movement, movement was strongly associated with transmission. This study demonstrates how integrative techniques may improve disease traceability in a data-rich era by providing a clearer picture of regional disease transmission.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.)
References: Mol Biol Evol. 2017 Apr 1;34(4):997-1007. (PMID: 28100788)
J Virol. 2005 Oct;79(19):12495-506. (PMID: 16160177)
Prev Vet Med. 2015 Mar 1;118(4):413-26. (PMID: 25636969)
Vaccine. 2015 May 15;33(21):2493-9. (PMID: 25820061)
Transbound Emerg Dis. 2019 Mar;66(2):823-830. (PMID: 30520570)
Arch Virol. 2016 Oct;161(10):2921-49. (PMID: 27424026)
Prev Vet Med. 2017 Mar 1;138:113-123. (PMID: 28237226)
Mol Biol Evol. 2005 Apr;22(4):1024-31. (PMID: 15659555)
Transbound Emerg Dis. 2022 Mar;69(2):485-500. (PMID: 33506620)
Epidemiol Infect. 2000 Feb;124(1):173-82. (PMID: 10722145)
Virus Evol. 2021 Jul 15;7(2):veab060. (PMID: 34532062)
Nucleic Acids Res. 2002 Jul 15;30(14):3059-66. (PMID: 12136088)
Mol Biol Evol. 2008 Jul;25(7):1459-71. (PMID: 18408232)
BMC Vet Res. 2014 Apr 05;10:83. (PMID: 24708804)
Sci Rep. 2017 Jun 28;7(1):4343. (PMID: 28659596)
J Virol. 2004 Aug;78(15):8094-101. (PMID: 15254181)
Microb Genom. 2016 May 31;2(5):e000060. (PMID: 28348853)
Transbound Emerg Dis. 2021 Mar;68(2):667-683. (PMID: 32657491)
Prev Vet Med. 2019 Mar 1;164:1-9. (PMID: 30771888)
Bioinformatics. 2014 May 1;30(9):1312-3. (PMID: 24451623)
BMC Bioinformatics. 2013 Nov 06;14:317. (PMID: 24191891)
Prev Vet Med. 2020 Jan;174:104856. (PMID: 31786406)
Arch Virol. 2021 Sep;166(9):2633-2648. (PMID: 34231026)
J Stat Softw. 2008 May 1;24(3):nihpa54860. (PMID: 19756229)
PLoS Biol. 2006 May;4(5):e88. (PMID: 16683862)
Can J Vet Res. 2002 Oct;66(4):232-9. (PMID: 12418778)
Virus Evol. 2015 May 26;1(1):vev003. (PMID: 27774277)
Front Microbiol. 2019 Nov 01;10:2486. (PMID: 31736919)
J Gen Virol. 2013 Oct;94(Pt 10):2141-2163. (PMID: 23939974)
Pathogens. 2022 Feb 15;11(2):. (PMID: 35215195)
Arch Virol. 1999;144(12):2389-401. (PMID: 10664392)
Transbound Emerg Dis. 2021 Jul;68(4):2334-2344. (PMID: 33113239)
Vet Microbiol. 2010 Oct 26;145(3-4):198-208. (PMID: 20418029)
BMC Evol Biol. 2007 Nov 08;7:214. (PMID: 17996036)
J Vet Diagn Invest. 2020 May;32(3):394-400. (PMID: 32274974)
Vaccines (Basel). 2021 Jun 05;9(6):. (PMID: 34198904)
Vet Res. 2012 Oct 12;43:69. (PMID: 23061672)
Can J Vet Res. 2004 Apr;68(2):128-33. (PMID: 15188957)
Virus Res. 2006 Apr;117(1):17-37. (PMID: 16503362)
Virus Res. 2010 Dec;154(1-2):104-13. (PMID: 20837070)
PLoS Pathog. 2018 Nov 1;14(11):e1007314. (PMID: 30383829)
Vet Res. 2016 Oct 28;47(1):108. (PMID: 27793195)
J Gen Virol. 2003 Jun;84(Pt 6):1535-1543. (PMID: 12771423)
Sci Rep. 2019 Mar 18;9(1):4809. (PMID: 30886211)
Virus Res. 2010 Dec;154(1-2):1-6. (PMID: 20951175)
J Virol. 2010 Sep;84(17):8700-11. (PMID: 20554771)
Transbound Emerg Dis. 2016 Apr;63(2):e251-61. (PMID: 25209832)
Virus Evol. 2016 Apr 09;2(1):vew007. (PMID: 27774300)
Prev Vet Med. 2021 May 3;191:105369. (PMID: 33965745)
Prev Vet Med. 2014 Sep 1;116(1-2):111-9. (PMID: 24931129)
Front Vet Sci. 2017 Apr 05;4:46. (PMID: 28424778)
PLoS One. 2017 Apr 17;12(4):e0172638. (PMID: 28414720)
Nat Methods. 2017 Jun;14(6):587-589. (PMID: 28481363)
Front Vet Sci. 2021 Jun 24;8:658512. (PMID: 34250057)
Viruses. 2019 Aug 03;11(8):. (PMID: 31382628)
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12680-12685. (PMID: 30463945)
Nature. 2018 Apr;556(7702):452-456. (PMID: 29670290)
Infect Genet Evol. 2016 Jun;40:167-175. (PMID: 26961593)
فهرسة مساهمة: Keywords: disease transmission; molecular epidemiology; network analysis; porcine reproductive and respiratory syndrome virus 2; reproduction number; traceability; transmission tree
تواريخ الأحداث: Date Created: 20231129 Latest Revision: 20231201
رمز التحديث: 20231201
مُعرف محوري في PubMed: PMC10660809
DOI: 10.1111/eva.13596
PMID: 38020873
قاعدة البيانات: MEDLINE
الوصف
تدمد:1752-4571
DOI:10.1111/eva.13596