دورية أكاديمية
Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis.
| العنوان: | Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis. |
|---|---|
| المؤلفون: | Wallace L; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, United States., Obeng EA; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, United States. |
| المصدر: | Frontiers in molecular biosciences [Front Mol Biosci] 2023 Oct 31; Vol. 10, pp. 1273046. Date of Electronic Publication: 2023 Oct 31 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653173 Publication Model: eCollection Cited Medium: Print ISSN: 2296-889X (Print) Linking ISSN: 2296889X NLM ISO Abbreviation: Front Mol Biosci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| مستخلص: | Hematopoiesis is an essential process for organismal development and homeostasis. Epigenetic regulation of gene expression is critical for stem cell self-renewal and differentiation in normal hematopoiesis. Increasing evidence shows that disrupting the balance between self-renewal and cell fate decisions can give rise to hematological diseases such as bone marrow failure and leukemia. Consequently, next-generation sequencing studies have identified various aberrations in histone modifications, DNA methylation, RNA splicing, and RNA modifications in hematologic diseases. Favorable outcomes after targeting epigenetic regulators during disease states have further emphasized their importance in hematological malignancy. However, these targeted therapies are only effective in some patients, suggesting that further research is needed to decipher the complexity of epigenetic regulation during hematopoiesis. In this review, an update on the impact of the epigenome on normal hematopoiesis, disease initiation and progression, and current therapeutic advancements will be discussed. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Wallace and Obeng.) |
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| معلومات مُعتمدة: | T32 CA236748 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: DNA methylation; RNA modification; clonal hematopoiesis; epigenetics; hematopoiesis; histone modification; splicing |
| تواريخ الأحداث: | Date Created: 20231129 Latest Revision: 20240718 |
| رمز التحديث: | 20240718 |
| مُعرف محوري في PubMed: | PMC10644717 |
| DOI: | 10.3389/fmolb.2023.1273046 |
| PMID: | 38028538 |
| قاعدة البيانات: | MEDLINE |
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