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Short-term effects of cyclopentolate and tropicamide eye drops on macular choroidal thickness in myopic children.

التفاصيل البيبلوغرافية
العنوان: Short-term effects of cyclopentolate and tropicamide eye drops on macular choroidal thickness in myopic children.
المؤلفون: Kobia-Acquah E; Centre for Eye Research Ireland, Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland., Flitcroft DI; Centre for Eye Research Ireland, Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland.; Department of Ophthalmology, Children's Health Ireland at Temple Street Hospital, Dublin, Ireland., Lingham G; Centre for Eye Research Ireland, Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland., Kerin E; Centre for Eye Research Ireland, Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland., Loughman J; Centre for Eye Research Ireland, Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland.
المصدر: Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) [Ophthalmic Physiol Opt] 2024 Mar; Vol. 44 (2), pp. 280-291. Date of Electronic Publication: 2023 Nov 30.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishers Country of Publication: England NLM ID: 8208839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-1313 (Electronic) Linking ISSN: 02755408 NLM ISO Abbreviation: Ophthalmic Physiol Opt Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : Oxford : Blackwell Publishers
Original Publication: Oxford ; New York : Pergamon Press, c1981-
مواضيع طبية MeSH: Myopia*/drug therapy , Presbyopia*, Child ; Humans ; Atropine ; Cyclopentolate ; Mydriatics ; Ophthalmic Solutions ; Tropicamide/pharmacology ; Tropicamide/therapeutic use ; Adolescent ; Young Adult
مستخلص: Background: To investigate the short-term effects of cyclopentolate and tropicamide eyedrops on choroidal thickness (ChT) in myopic children using placebo or low-dose atropine eyedrops.
Methods: The analysis included 242 myopic individuals (7-19 years) enrolled in two randomised placebo-controlled clinical trials of low-dose atropine eyedrops. Cycloplegia was induced using either one drop of 1% cyclopentolate (n = 161), two drops of 1% cyclopentolate (n = 32) or two drops of 1% tropicamide (n = 49). ChT measurements were taken using swept-source optical coherence tomography before and 30 min after administering the cycloplegic eye drops. A subset of 51 participants underwent test-retest measurements prior to cycloplegia.
Results: Mean changes in subfoveal ChT after two drops of tropicamide and one and two drops of cyclopentolate were -2.5 μm (p = 0.10), -4.3 μm (p < 0.001) and -9.6 μm (p < 0.001), respectively. Subfoveal ChT changes after one and two drops of cyclopentolate were significantly greater than the test-retest changes (test-retest mean change: -3.1 μm; p < 0.05), while the tropicamide group was not significantly different (p = 0.64). Choroidal thinning post-cyclopentolate was not significantly different between atropine and placebo treatment groups (p > 0.05 for all macular locations). The coefficient of repeatability (CoR) in the tropicamide group (range: 8.2-14.4 μm) was similar to test-retest (range: 7.5-12.2 μm), whereas greater CoR values were observed in the cyclopentolate groups (one drop: range: 10.8-15.3 μm; two drops: range: 12.2-24.6 μm).
Conclusions: Cyclopentolate eye drops caused dose-dependent choroidal thinning and increased variation in pre- to post-cycloplegia measurements compared with test-retest variability, whereas tropicamide did not. These findings have practical implications for ChT measurements when cyclopentolate is used, particularly for successive measurements.
(© 2023 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists.)
References: Read SA, Alonso-Caneiro D, Vincent SJ, Collins MJ. Longitudinal changes in choroidal thickness and eye growth in childhood. Invest Ophthalmol Vis Sci. 2015;56:3103-3110.
Liu Y, Wang L, Xu Y, Pang Z, Mu G. The influence of the choroid on the onset and development of myopia: from perspectives of choroidal thickness and blood flow. Acta Ophthalmol. 2021;99:730-738.
Xiong S, He X, Zhang B, Deng J, Wang J, Lv M, et al. Changes in choroidal thickness varied by age and refraction in children and adolescents: a 1-year longitudinal study. Am J Ophthalmol. 2020;213:46-56.
Wallman J, Wildsoet C, Xu A, Gottlieb M, Nickla D, Marran L, et al. Moving the retina: choroidal modulation of refractive state. Vision Res. 1995;35:37-50.
Summers J. The choroid as a sclera growth regulator. Exp Eye Res. 2013;114:120-127.
Li Z, Wang W, Liu R, Wang D, Zhang J, Xiao O, et al. Choroidal thickness predicts progression of myopic maculopathy in high myopes: a 2-year longitudinal study. Br J Ophthalmol. 2020;105:1744-1750.
Huang Y, Li X, Wu J, Huo J, Zhou F, Zhang J, et al. Effect of spectacle lenses with aspherical lenslets on choroidal thickness in myopic children: a 2-year randomised clinical trial. Br J Ophthalmol. 2022;107:bjophthalmol-2022-321815. https://doi.org/10.1136/bjo-2022-321815.
Hao Q, Zhao Q. Changes in subfoveal choroidal thickness in myopic children with 0.01% atropine, orthokeratology, or their combination. Int Ophthalmol. 2021;41:2963-2971.
Chen Z, Xue F, Zhou J, Qu X, Zhou X. Effects of orthokeratology on choroidal thickness and axial length. Optom Vis Sci. 2016;93:1064-1071.
Li Z, Hu Y, Cui D, Long W, He M, Yang X. Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length. Acta Ophthalmol. 2019;97:e454-e459.
Yam J, Jiang Y, Lee J, Li S, Zhang Y, Sun W, et al. The association of choroidal thickening by atropine with treatment effects for myopia: two-year clinical trial of the LAMP study. Am J Ophthalmol. 2021; 237:130-8.
Gifford KL, Richdale K, Kang P, Aller TA, Lam CS, Liu YM, et al. IMI - clinical management guidelines report. Invest Ophthalmol Vis Sci. 2019;60:M184-M203.
Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye. 2016;30:925-928.
Yuvacı İ, Pangal E, Yuvacı S, Bayram N, Ataş M, Başkan B, et al. An evaluation of effects of different mydriatics on choroidal thickness by examining anterior chamber parameters: the Scheimpflug imaging and enhanced depth imaging-OCT study. J Ophthalmol. 2015;2015:981274. https://doi.org/10.1155/2015/981274.
Kara N, Demircan A, Karatas G, Ozgurhan E, Tatar G, Karakucuk Y, et al. Effects of two commonly used mydriatics on choroidal thickness: direct and crossover effects. J Ocul Pharmacol Ther. 2014;30:366-370.
Bahar A, Pekel G. The effects of pharmacological accommodation and cycloplegia on axial length and choroidal thickness. Arq Bras Oftalmol. 2021;84:107-112.
Iovino C, Chhablani J, Rasheed MA, Tatti F, Bernabei F, Pellegrini M, et al. Effects of different mydriatics on the choroidal vascularity in healthy subjects. Eye. 2020;35:913-918.
Mwanza JC, Sayyad FE, Banitt MR, Budenz DL. Effect of pupil dilation on macular choroidal thickness measured with spectral domain optical coherence tomography in normal and glaucomatous eyes. Int Ophthalmol. 2013;33:335-341.
Ye L, Li S, Shi Y, Yin Y, He J, Zhu J, et al. Comparisons of atropine versus cyclopentolate cycloplegia in myopic children. Clin Exp Optom. 2021;104:143-150.
McCrann S, Flitcroft I, Strang N, Saunders K, Logan N, Lee S, et al. Myopia outcome study of atropine in children (MOSAIC): an investigator-led, double-masked, placebo-controlled, randomised clinical trial protocol. HRB Open Res. 2019;2:15. https://doi.org/10.12688/hrbopenres.12914.1.
Kobia-Acquah E, Flitcroft DI, Lingham G, Paudel N, Loughman J. Choroidal thickness profiles and associated factors in myopic children. Optom Vis Sci. 2023;100:57-66.
Doyle M, O'Dwyer V, Harrington S. Comparison of cycloplegia at 20-and 30-minutes following proxymetacaine and cyclopentolate instillation in white 12-13-year-olds. Clin Exp Optom. 2023;106:890-895.
Manny R, Hussein M, Scheiman M, Kurtz D, Niemann K, Zinzer K, et al. Tropicamide (1%): an effective cycloplegic agent for myopic children. Invest Ophthalmol Vis Sci. 2001;42:1728-1735.
Gabriel M, Esmaeelpour M, Shams-Mafi F, Hermann B, Zabihian B, Drexler W, et al. Mapping diurnal changes in choroidal, Haller's and Sattler's layer thickness using 3-dimensional 1060-nm optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2017;255:1957-1963.
Brown J, Flitcroft D, Ying G, Francis E, Schmid G, Quinn G, et al. In vivo human choroidal thickness measurements: evidence for diurnal fluctuations. Invest Ophthalmol Vis Sci. 2009;50:5-12.
Sampson DM, Gong P, An D, Menghini M, Hansen A, Mackey DA, et al. Axial length variation impacts on superficial retinal vessel density and foveal avascular zone area measurements using optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2017;58:3065-3072.
Bennett AG, Rudnicka AR, Edgar DF. Improvements on Littmann's method of determining the size of retinal features by fundus photography. Graefes Arch Clin Exp Ophthalmol. 1994;232:361-367.
Martin Bland J, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;327:307-310.
Armstrong R. Statistical guidelines for the analysis of data obtained from one or both eyes. Ophthalmic Physiol Opt. 2013;33:7-14.
Murdoch I, Morris S, Cousens SN. People and eyes: statistical approaches in ophthalmology. Br J Ophthalmol. 1998;82:971-973.
Lanier O, Manfre M, Bailey C, Liu Z, Sparks Z, Kulkarni S, et al. Review of approaches for increasing ophthalmic bioavailability for eye drop formulations. AAPS PharmSciTech. 2021;22:107. https://doi.org/10.1208/s12249-021-01977-0.
Troilo D, Smith E, Nickla D, Ashby R, Tkatchenko A, Ostrin L, et al. IMI-report on experimental models of emmetropization and myopia. Invest Ophthalmol Vis Sci. 2019;60:M31-M88.
Nickla D, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29:144-168.
Nickla D, Zhu X, Wallman J. Effects of muscarinic agents on chick choroids in intact eyes and eyecups: evidence for a muscarinic mechanism in choroidal thinning. Ophthalmic Physiol Opt. 2013;33:245-256.
Lütjen-Drecoll E. Choroidal innervation in primate eyes. Exp Eye Res. 2006;82:357-361.
Croft M, Nork T, McDonald J, Katz A, Lütjen-Drecoll E, Kaufman P. Accommodative movements of the vitreous membrane, choroid, and sclera in young and presbyopic human and nonhuman primate eyes. Invest Ophthalmol Vis Sci. 2013;54:5049-5058.
Nickla DL, Damyanova P, Lytle G. Inhibiting the neuronal isoform of nitric oxide synthase has similar effects on the compensatory choroidal and axial responses to myopic defocus in chicks as does the non-specific inhibitor l-NAME. Exp Eye Res. 2009;88:1092-1099.
Mathis U, Feldkaemper M, Liu H, Schaeffel F. Studies on the interactions of retinal dopamine with choroidal thickness in the chicken. Graefes Arch Clin Exp Ophthalmol. 2023;261:409-425.
Bartlett J, Frost C. Reliability, repeatability and reproducibility: analysis of measurement errors in continuous variables. Ultrasound Obstet Gynecol. 2008;31:466-475.
Li S, Pan Y, Xu J, Li X, Spiegel D, Bao J, et al. Effects of physical exercise on macular vessel density and choroidal thickness in children. Sci Rep. 2021;11:2015. https://doi.org/10.1038/s41598-021-81770-y.
Mansouri K, Medeiros FA, Marchase N, Tatham AJ, Auerbach D, Weinreb RN. Assessment of choroidal thickness and volume during the water drinking test by swept-source optical coherence tomography. Ophthalmology. 2013;120:2508-2516.
Zengin M, Cinar E, Karahan E, Tuncer I, Kucukerdonmez C. The effect of caffeine on choroidal thickness in young healthy subjects. Cutan Ocul Toxicol. 2015;34:112-116.
Asmussen A, Smith B, Møller F, Jakobsen T. Repeatability and inter-observer variation of choroidal thickness measurements using swept-source optical coherence tomography in myopic Danish children aged 6-14 years. Acta Ophthalmol. 2022;100:74-81.
معلومات مُعتمدة: MRCG 2016-13 Fighting Blindness Ireland; Health Research Board Ireland; Topcon Europe Medical
فهرسة مساهمة: Keywords: choroidal thickness; cyclopentolate; myopic children; tropicamide
المشرفين على المادة: 7C0697DR9I (Atropine)
I76F4SHP7J (Cyclopentolate)
0 (Mydriatics)
0 (Ophthalmic Solutions)
N0A3Z5XTC6 (Tropicamide)
تواريخ الأحداث: Date Created: 20231201 Date Completed: 20240220 Latest Revision: 20240220
رمز التحديث: 20240220
DOI: 10.1111/opo.13256
PMID: 38037443
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-1313
DOI:10.1111/opo.13256