دورية أكاديمية
أعرض في EDS

Antibiotic-Resistant Arcobacter spp. in commercial and smallholder farm animals in Asante Akim North Municipality, Ghana and Korogwe Town Council, Tanzania: a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Antibiotic-Resistant Arcobacter spp. in commercial and smallholder farm animals in Asante Akim North Municipality, Ghana and Korogwe Town Council, Tanzania: a cross-sectional study.
المؤلفون: Paintsil EK; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), South-End, Asuogya Road, 039-5028, Kumasi, Ghana. paintsil@kccr.de.; Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, 039-5028, Kumasi, Ghana. paintsil@kccr.de.; Department of Implementation Research, One Health Bacteriology Group, Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany. paintsil@kccr.de., Ofori LA; Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, 039-5028, Kumasi, Ghana., Akenten CW; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), South-End, Asuogya Road, 039-5028, Kumasi, Ghana.; Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, 039-5028, Kumasi, Ghana.; Department of Implementation Research, One Health Bacteriology Group, Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany., Zautner AE; Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Otto-Von-Guericke University Magdeburg, 39120, Magdeburg, Germany., Mbwana J; National Institute for Medical Research (NIMR), Tanga Centre, Tanga, Tanzania., Khan NA; Department of Implementation Research, One Health Bacteriology Group, Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany., Lusingu JPA; National Institute for Medical Research (NIMR), Tanga Centre, Tanga, Tanzania., Kaseka J; National Institute for Medical Research (NIMR), Tanga Centre, Tanga, Tanzania., Minja DTR; National Institute for Medical Research (NIMR), Tanga Centre, Tanga, Tanzania., Gesase S; National Institute for Medical Research (NIMR), Tanga Centre, Tanga, Tanzania., Jaeger A; Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany., Lamshöft M; Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.; German Centre for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, 20359, Hamburg, Germany., May J; Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.; German Centre for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, 20359, Hamburg, Germany.; Tropical Medicine II, University Medical Center Hamburg-Eppendorf (UKE), 20251, Hamburg, Germany., Obiri-Danso K; Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, 039-5028, Kumasi, Ghana., Krumkamp R; Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.; German Centre for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, 20359, Hamburg, Germany., Dekker D; Department of Implementation Research, One Health Bacteriology Group, Bernhard Nocht Institute for Tropical Medicine (BNITM), Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.
المصدر: Gut pathogens [Gut Pathog] 2023 Dec 02; Vol. 15 (1), pp. 63. Date of Electronic Publication: 2023 Dec 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101474263 Publication Model: Electronic Cited Medium: Print ISSN: 1757-4749 (Print) Linking ISSN: 17574749 NLM ISO Abbreviation: Gut Pathog Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مستخلص: Background: Arcobacter species are considered emerging foodborne pathogens that can potentially cause serious infections in animals and humans. This cross-sectional study determined the frequency of potentially pathogenic Arcobacter spp. in both commercial and smallholder farm animals in Ghana and Tanzania. A total of 1585 and 1047 (poultry and livestock) samples were collected in Ghana and Tanzania, respectively. Selective enrichment media, along with oxidase and Gram testing, were employed for isolation of suspected Arcobacter spp. and confirmation was done using MALDI-TOF MS. Antibiotic susceptibility was assessed through disk diffusion method and ECOFFs were generated, for interpretation, based on resulting inhibition zone diameters.
Results: The overall Arcobacter frequency was higher in Ghana (7.0%, n = 111) than in Tanzania (2.0%, n = 21). The frequency of Arcobacter in commercial farms in Ghana was 10.3% (n/N = 83/805), while in Tanzania, it was 2.8% (n/N = 12/430). Arcobacter was detected in only 3.6% (n/N = 28/780) of the samples from smallholder farms in Ghana and 1.5% (n/N = 9/617) of the samples from Tanzania. For commercial farms, in Ghana, the presence of Arcobacter was more abundant in pigs (45.1%, n/N = 37/82), followed by ducks (38.5%, n/N = 10/26) and quails (35.7%, n/N = 10/28). According to MALDI-TOF-based species identification, Arcobacter butzleri (91.6%, n/N = 121/132), Arcobacter lanthieri (6.1%, n/N = 8/132), and Arcobacter cryaerophilus (2.3%, n/N = 3/132) were the only three Arcobacter species detected at both study sites. Almost all of the Arcobacter from Ghana (98.2%, n/N = 109/111) were isolated during the rainy season. The inhibition zone diameters recorded for penicillin, ampicillin, and chloramphenicol allowed no determination of an epidemiological cut-off value. However, the results indicated a general resistance to these three antimicrobials. Multidrug resistance was noted in 57.1% (n/N = 12/21) of the Arcobacter isolates from Tanzania and 45.0% (n/N = 50/111) of those from Ghana. The type of farm (commercial or smallholder) and source of the sample (poultry or livestock) were found to be associated with multi-drug resistance.
Conclusions: The high levels of MDR Arcobacter detected from farms in both countries call for urgent attention and comprehensive strategies to mitigate the spread of antimicrobial resistance in these pathogens.
(© 2023. The Author(s).)
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معلومات مُعتمدة: 649070 Deutsche Forschungsgemeinschaft
فهرسة مساهمة: Keywords: Antimicrobial resistance; Arcobacter; Arcobacter butzleri; Arcobacter cryaerophilus; Arcobacter lanthieri; Commercial farms; Ghana; Smallholder farms; Tanzania
تواريخ الأحداث: Date Created: 20231202 Latest Revision: 20231205
رمز التحديث: 20231205
مُعرف محوري في PubMed: PMC10693124
DOI: 10.1186/s13099-023-00588-3
PMID: 38042805
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-4749
DOI:10.1186/s13099-023-00588-3