دورية أكاديمية
Mass spectrometry as a tool for the dereplication of specialised metabolites from Pterocaulon angustifolium DC.
| العنوان: | Mass spectrometry as a tool for the dereplication of specialised metabolites from Pterocaulon angustifolium DC. |
|---|---|
| المؤلفون: | Moreno BP; Departamento de Química, Universidade Estadual de Maringá, UEM, Maringá, PR, Brazil., Pereira FA; Departamento de Química, Universidade Estadual de Maringá, UEM, Maringá, PR, Brazil., Andrade AAR; Departamento de Química, Universidade Estadual de Maringá, UEM, Maringá, PR, Brazil., Cabral MRP; Departamento de Química, Universidade Estadual de Maringá, UEM, Maringá, PR, Brazil., Battistella AC; Assuntos regulatórios, Universidade Tecnológica Federal do Paraná, R. Cristo Rei, Toledo, PR, Brazil., Tiuman TS; Assuntos regulatórios, Universidade Tecnológica Federal do Paraná, R. Cristo Rei, Toledo, PR, Brazil., Foglio MA; Faculdade de Ciências Farmacêuticas, UNICAMP, Rua Cândido Portinari, Campinas, SP, Brazil., Ruiz ALTG; Faculdade de Ciências Farmacêuticas, UNICAMP, Rua Cândido Portinari, Campinas, SP, Brazil., do Carmo MRB; Departamento de Biologia Geral, Universidade Estadual de Ponta Grossa, UEPG, Ponta Grossa, PR, Brazil., Sarragiotto MH; Departamento de Química, Universidade Estadual de Maringá, UEM, Maringá, PR, Brazil., Baldoqui DC; Departamento de Química, Universidade Estadual de Maringá, UEM, Maringá, PR, Brazil. |
| المصدر: | Natural product research [Nat Prod Res] 2023 Dec 03, pp. 1-8. Date of Electronic Publication: 2023 Dec 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مستخلص: | Pterocaulon genus comprises 26 species, half of them have been phytochemical investigations regarding the chemical composition, and coumarins have been considered the chemotaxonomic markers in the genus. Herein Pterocaulon angustifolium DC (Asteraceae), a native plant from Brazil, is investigated for the first time. Twenty-six compounds were isolated from aerial parts of P. angustifolium DC., being 5 triterpenes, 4 phytosterols, 9 flavonoids, 3 phenolic acids, and 5 coumarins. Moreover, a total of 177 compounds were putatively identified using the dereplication technique by UHPLC-HRMS/MS, more than 50% correspond to flavonoids and coumarins. Although 41 different coumarins have already been reported in Pterocaulon genus, 16 were identified for the first time in this study. Crude ethanolic extract and fractions of P. angustifolium were also biologically investigates, and dichloromethane fraction was the most active fraction in the evaluation of antiproliferative, antioxidant, antimicrobial and cholinesterase inhibitory activities. |
| فهرسة مساهمة: | Keywords: Coumarins; antimicrobial activity; antioxidant activity; cholinesterase inhibitory activities; dereplication; prenylated flavonoids |
| تواريخ الأحداث: | Date Created: 20231203 Latest Revision: 20231203 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14786419.2023.2284863 |
| PMID: | 38043103 |
| قاعدة البيانات: | MEDLINE |
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