دورية أكاديمية
أعرض في EDS

Clinical Implications of Adding SPECT/CT to Radioiodine Whole-Body Scan in Patients With Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Clinical Implications of Adding SPECT/CT to Radioiodine Whole-Body Scan in Patients With Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis.
المؤلفون: Chong A; From the Department of Nuclear Medicine, Chosun University, College of Medicine and Chosun University Hospital, Gwangju., Seo Y; Department of Nuclear Medicine, Chungnam National University Sejong Hospital, Sejong., Bang JI; Department of Nuclear Medicine, CHA Bundang Medical Center, CHA University, Pocheon., Park S; Department of Nuclear Medicine, Hospital, National Cancer Center, Goyang., Kim K; Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital and School of Medicine, Pusan National University, Busan., Hong CM; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu., Choi M; Division of Health Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency., Oh SW; Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul., Lee SW; Department of Nuclear Medicine, Kyungpook National University, School of Medicine and Chilgok Hospital, Daegu, South Korea.
المصدر: Clinical nuclear medicine [Clin Nucl Med] 2024 Mar 01; Vol. 49 (3), pp. 215-225. Date of Electronic Publication: 2023 Dec 01.
نوع المنشور: Meta-Analysis; Systematic Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, Lippincott.
مواضيع طبية MeSH: Thyroid Neoplasms*/diagnostic imaging , Thyroid Neoplasms*/drug therapy , Adenocarcinoma*/drug therapy, Humans ; Iodine Radioisotopes/therapeutic use ; Whole Body Imaging ; Retrospective Studies ; Prospective Studies ; Single Photon Emission Computed Tomography Computed Tomography ; Tomography, Emission-Computed, Single-Photon/methods
مستخلص: Purpose: This study aimed to determine the usefulness of adding SPECT/CT to radioiodine whole-body scans (WBSs) for the treatment of differentiated thyroid cancer (DTC).
Patients and Methods: A systematic review and meta-analysis were performed following the PRISMA guidelines (PROSPERO registration: CRD42022341732) to compare the feasibility of conclusive readings and the frequency of changes in treatment plans in patients with DTC undergoing WBS + SPECT/CT versus WBS. MEDLINE, EMBASE, and Cochrane databases were searched to identify relevant articles concerning thyroid cancer, radioactive iodine, and SPECT/CT or SPECT, published before August 16, 2023. Studies not comparing WBS + SPECT/CT with WBS, those lacking target outcomes, and those not involving human subjects were excluded. The risk of bias was assessed using the RoBANS 2.0 (Risk of Bias Assessment Tool for Nonrandomized Studies) tool. The GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) system was used to evaluate the quality of evidence and strength of recommendations.
Results: A total of 30 studies (prospective n = 9, retrospective n = 21) were included in the meta-analyses. Adding SPECT/CT to WBS was shown to increase conclusive readings for cervical lesions, extracervical lesions, and all regions. Lesion-based analyses showed improvements of 14%, 20%, and 18%, respectively, whereas scan-based analyses showed improvements of 27%, 9%, and 34%. The addition of SPECT/CT to WBS led to changes in 30% of treatment plans after diagnostic scans and 9% of treatment plans after posttherapeutic scans. The quality of evidence and strength of recommendations were low.
Conclusions: Compelling evidence demonstrates that the addition of SPECT/CT to WBS improves lesion localization, diagnostic performance, and therapy plan for patients with DTC.
Competing Interests: Conflicts of interest and sources of funding: All authors declare that they have no conflict of interest. This work was supported by the National Cancer Center Grant (NCC-2112570-1).
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: 0 (Iodine Radioisotopes)
تواريخ الأحداث: Date Created: 20231204 Date Completed: 20240205 Latest Revision: 20240205
رمز التحديث: 20240205
DOI: 10.1097/RLU.0000000000004953
PMID: 38048517
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-0229
DOI:10.1097/RLU.0000000000004953