دورية أكاديمية
Impact of aminopenicillin administration routes on antimicrobial effects of platelet-rich fibrin: An in-vitro investigation.
| العنوان: | Impact of aminopenicillin administration routes on antimicrobial effects of platelet-rich fibrin: An in-vitro investigation. |
|---|---|
| المؤلفون: | Straub A; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, Würzburg 97070, Germany. Electronic address: Straub_A@ukw.de., Utz C; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, Würzburg 97070, Germany., Stapf M; Institute for Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany., Vollmer A; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, Würzburg 97070, Germany., Breitenbuecher N; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, Würzburg 97070, Germany., Kübler AC; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, Würzburg 97070, Germany., Brands RC; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, Würzburg 97070, Germany., Hartmann S; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, Würzburg 97070, Germany., Lâm TT; Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Straße 2/E1, Würzburg 97080, Germany. |
| المصدر: | Journal of stomatology, oral and maxillofacial surgery [J Stomatol Oral Maxillofac Surg] 2024 Jun; Vol. 125 (3), pp. 101725. Date of Electronic Publication: 2023 Dec 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101701089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-7855 (Electronic) Linking ISSN: 24687855 NLM ISO Abbreviation: J Stomatol Oral Maxillofac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Issy les Moulineaux Cedex : Elsevier Masson SAS, [2017]- |
| مواضيع طبية MeSH: | Platelet-Rich Fibrin* , Sulbactam*/pharmacology , Sulbactam*/administration & dosage , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/administration & dosage, Humans ; Administration, Oral ; Ampicillin/pharmacology ; Ampicillin/administration & dosage ; Haemophilus influenzae/drug effects ; Amoxicillin-Potassium Clavulanate Combination/administration & dosage ; Amoxicillin-Potassium Clavulanate Combination/pharmacology ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/physiology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology ; In Vitro Techniques ; Escherichia coli/drug effects ; Escherichia coli/physiology ; Male ; Porphyromonas gingivalis/drug effects ; Porphyromonas gingivalis/physiology ; Microbial Sensitivity Tests ; Female ; Adult ; Drug Administration Routes ; Middle Aged |
| مستخلص: | Introduction: The aim of the study was to investigate the impact of different aminopenicillin administration routes on the antimicrobial effects of platelet-rich fibrin (PRF). Methods: We enrolled patients undergoing treatment with amoxicillin/clavulanic acid (AMC) orally or ampicillin/sulbactam (SAM) intravenously. AMC was applied in a single oral dose (875/125 mg), or in a double oral dose (1750/250 mg), and SAM in a dose of 2000/1000 mg. Blood was obtained one hour after the intake of AMC or 15 min after the infusion of SAM ended. Antimicrobial effects were investigated in agar diffusion tests with fresh PRF, PRF stored for 24, and PRF stored for 48 h. Agar diffusion tests were performed with Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Porphyromonas gingivalis. Inhibition zones (IZs) around a 6 mm PRF disc were measured after 24 h. Results: IZs for fresh PRF and the single oral dose of AMC were 0.0, 4.7, 15.2, 2.3, and 0.9 mm (E. coli, S. aureus, S. pneumoniae, H. influenzae, and P. gingivalis, respectively). For the double oral dose, these values were 0.0, 11.4, 20.0, 8.1, and 7.4 mm. IZs for SAM were 11.9, 18.2, 24.7, 20.3, and 22.1 mm. Differences between parenteral and oral application as well as between different oral doses were significant (p<0.0001, one-way ANOVA). Discussion: The results of our study demonstrate that oral administration is a suitable route to load PRF with these drugs. This could expand the scope of PRF application to prevent infections at the surgical site, especially in an outpatient setting in which drugs are normally applied orally. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amoxicillin; Ampicillin; Carrier; Drug delivery; Local antibiotic application; PRF |
| المشرفين على المادة: | S4TF6I2330 (Sulbactam) 0 (Anti-Bacterial Agents) 7C782967RD (Ampicillin) 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination) 65DT0ML581 (sultamicillin) |
| تواريخ الأحداث: | Date Created: 20231204 Date Completed: 20240430 Latest Revision: 20240430 |
| رمز التحديث: | 20240430 |
| DOI: | 10.1016/j.jormas.2023.101725 |
| PMID: | 38048907 |
| قاعدة البيانات: | MEDLINE |
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