دورية أكاديمية
Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles.
| العنوان: | Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles. |
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| المؤلفون: | Zhang L; Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400037, China; Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China., Sunchen S; Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China., Lu C; Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China., Xu F; Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400037, China. Electronic address: xufeng9899@163.com., Dong H; Department of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400037, China; Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China. Electronic address: donghui@qdu.edu.cn. |
| المصدر: | Biochemical pharmacology [Biochem Pharmacol] 2024 Jan; Vol. 219, pp. 115961. Date of Electronic Publication: 2023 Dec 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford, New York [etc.] Paragamon Press. |
| مواضيع طبية MeSH: | Arterioles*/metabolism , Arterioles*/physiology , TRPV Cation Channels*/genetics , TRPV Cation Channels*/metabolism , Vasodilation*/genetics , Receptors, G-Protein-Coupled*/metabolism, Animals ; Humans ; Mice ; Endothelial Cells/metabolism ; Endothelium, Vascular/metabolism ; Zinc/metabolism |
| مستخلص: | Background: The micronutrient zinc (Zn 2+ ) is critical for cell function as intracellular signaling and endogenous ligand for Zn 2+ sensing receptor (ZnR). Although cytosolic Zn 2+ ( Methods: ZnR-mediated relaxation response of human submucosal arterioles and the mesenteric arterioles from wide-type (WT), ZnR -/- and TRPV4 -/- mice were determined by a Mulvany-style wire myograph. The perfused vessel density (PVD) of mouse mesenteric arterioles was also measured in in vivo study. The expression of ZnR in arterioles and vascular endothelial cells (VEC) were examined by immunofluorescence staining, and its function was characterized in VEC by Ca 2+ imaging and patch clamp study. Results: ZnR expression was detected on human submucosal arterioles, murine mesenteric arterioles and VEC but not in ZnR -/- mice. ZnR activation predominately induced endothelium-dependent hyperpolarization (EDH)-mediated vasorelaxation of arterioles in vitro and in vivo via Ca 2+ signaling, which is totally different from endothelium-dependent vasorelaxation via Zn 2+ ( Conclusion: ZnR activation induces endothelium-dependent vasorelaxation of resistance vessels predominately via TRPV4/Ca 2+ /EDH pathway. We therefore not only provide new insights into physiological role of ZnR in vascular system but also may pave a potential pathway for developing Zn 2+ -based treatments for vascular disease. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: Endothelium-derived hyperpolarization; SOCE; TRPV4; Zn(2+) sensing receptor |
| المشرفين على المادة: | 0 (TRPV Cation Channels) J41CSQ7QDS (Zinc) 0 (GPR39 protein, human) 0 (Receptors, G-Protein-Coupled) |
| تواريخ الأحداث: | Date Created: 20231204 Date Completed: 20231226 Latest Revision: 20240403 |
| رمز التحديث: | 20240404 |
| DOI: | 10.1016/j.bcp.2023.115961 |
| PMID: | 38049010 |
| قاعدة البيانات: | MEDLINE |
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