دورية أكاديمية
أعرض في EDS

High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood.

التفاصيل البيبلوغرافية
العنوان: High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood.
المؤلفون: Maldonado-Ruiz LP; Department of Entomology, Kansas State University, Manhattan, KS, 66506, USA., Reif KE; Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA., Ghosh A; Department of Biology, Pittsburg State University, Pittsburg, KS, 66762, USA., Foré S; Department of Biology, Truman State University, Kirksville, MO, 63501, USA., Johnson RL; Department of Entomology, Kansas State University, Manhattan, KS, 66506, USA., Park Y; Department of Entomology, Kansas State University, Manhattan, KS, 66506, USA. ypark@ksu.edu.
المصدر: Scientific reports [Sci Rep] 2023 Dec 04; Vol. 13 (1), pp. 21409. Date of Electronic Publication: 2023 Dec 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Tick Bites* , Food Hypersensitivity* , Ticks*, Animals ; Humans ; Female ; Amblyomma ; Galactose ; Immunoglobulin E ; Salivary Glands ; Mammals
مستخلص: Tick bites, associated with the secretion of tick saliva containing the xenoglycan galactose-alpha-1, 3-galactose (alpha-gal or aGal), are recognized as the causal factors of alpha-Gal syndrome (AGS; or red meat allergy) in humans. AGS occurs after the increased production of IgE antibodies against aGal, which is found in most mammalian cells, except for the Old World monkey and humans. The aGal sensitization event has been linked to an initial tick bite, followed by consumption of red meat containing the aGal glycan, which triggers the onset of the allergic response resulting in urticaria, anaphylaxis, or even death. In North America, the lone star tick, Amblyomma americanum, has been identified as the main culprit for AGS. However, only a subset of the human population exposed to lone star tick bites develops AGS. This suggests the presence of unidentified variables associated with the sensitization event. To evaluate the quantitative variations of the aGal in ticks, we evaluated the differences in aGal levels in different strains of A. americanum ticks partially fed on different blood sources using an artificial feeding system and animal hosts. We found significantly higher aGal levels in the female ticks fed on human blood than those fed on the blood of other mammals with large variations among different tick populations and individuals. We propose that host-specific genetic components in the A. americanum ticks are involved in the production of high aGal epitope in the tick saliva, which provides a part of the explanation for the variables associated with the AGS sensitization event of the tick bite.
(© 2023. The Author(s).)
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معلومات مُعتمدة: R21 AI163423 United States AI NIAID NIH HHS; R21 AI163423 United States NH NIH HHS
المشرفين على المادة: X2RN3Q8DNE (Galactose)
37341-29-0 (Immunoglobulin E)
SCR Disease Name: red meat allergy
تواريخ الأحداث: Date Created: 20231204 Date Completed: 20231206 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10695944
DOI: 10.1038/s41598-023-48437-2
PMID: 38049505
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-023-48437-2