دورية أكاديمية
Beyond cardiovascular risk: Implications of Familial hypercholesterolemia on cognition and brain function.
| العنوان: | Beyond cardiovascular risk: Implications of Familial hypercholesterolemia on cognition and brain function. |
|---|---|
| المؤلفون: | de Oliveira J; Laboratory of investigation on metabolic disorders and neurodegenerative diseases, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil. Electronic address: deoliveirajade10@gmail.com., Moreira ELG; Neuroscience Coworking Lab, Department of Physiological Sciences, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: eduardo.luiz@ufsc.br., de Bem AF; Laboratory of Bioenergetics and Metabolism, Department of Physiological Sciences, University of Brasilia, Brasília, Federal District, DF 70910-900, Brazil; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Brazilian National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Foundation, Rio de Janeiro, RJ 21040360, Brazil. Electronic address: debemandreza@gmail.com. |
| المصدر: | Ageing research reviews [Ageing Res Rev] 2024 Jan; Vol. 93, pp. 102149. Date of Electronic Publication: 2023 Dec 04. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | Hypercholesterolemia*/epidemiology , Hypercholesterolemia*/genetics , Hypercholesterolemia*/metabolism , Cardiovascular Diseases*/genetics , Hyperlipoproteinemia Type II*/complications , Hyperlipoproteinemia Type II*/genetics , Alzheimer Disease*, Humans ; Animals ; Mice ; Risk Factors ; Brain/metabolism ; Cognition ; Heart Disease Risk Factors |
| مستخلص: | Familial hypercholesterolemia (FH) is a metabolic condition caused mainly by a mutation in the low-density lipoprotein (LDL) receptor gene (LDLR), which is highly prevalent in the population. Besides being an important causative factor of cardiovascular diseases, FH has been considered an early risk factor for Alzheimer's disease. Cognitive and emotional behavioral impairments in LDL receptor knockout (LDLr -/- ) mice are associated with neuroinflammation, blood-brain barrier dysfunction, impaired neurogenesis, brain oxidative stress, and mitochondrial dysfunction. Notably, today, LDLr -/- mice, a widely used animal model for studying cardiovascular diseases and atherosclerosis, are also considered an interesting tool for studying dementia. Here, we reviewed the main findings in LDLr -/- mice regarding the relationship between FH and brain dysfunctions and dementia development. Competing Interests: Declaration of Competing Interest None. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Blood-brain barrier, Neuroinflammation, LDL receptor, LDLr(-/-) mice; Cholesterol; Memory |
| تواريخ الأحداث: | Date Created: 20231206 Date Completed: 20240109 Latest Revision: 20240701 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1016/j.arr.2023.102149 |
| PMID: | 38056504 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1872-9649 |
|---|---|
| DOI: | 10.1016/j.arr.2023.102149 |