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Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea .

التفاصيل البيبلوغرافية
العنوان: Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea .
المؤلفون: Huang SW; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Hsu MJ; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chen HC; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Meleddu R; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy., Distinto S; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy., Maccioni E; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy., Cottiglia F; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy.
المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2287420. Date of Electronic Publication: 2023 Dec 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basingstoke, UK : Taylor & Francis, c2002-
مواضيع طبية MeSH: Benzofurans*/pharmacology , Glycosides*/pharmacology, CCAAT-Enhancer-Binding Protein-beta/metabolism ; Cyclooxygenase 2/metabolism ; Lipopolysaccharides/pharmacology ; NF-kappa B/metabolism ; Phosphorylation ; p38 Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Kinase 4/metabolism ; Magnoliopsida/chemistry
مستخلص: The phytochemical investigation of the methanol extract of the seeds of Magydaris pastinacea afforded two undescribed benzofuran glycosides, furomagydarins A-B ( 1 , 2 ), together with three known coumarins. The structures of the new isolates were elucidated after extensive 1D and 2D NMR experiments as well as HR MS. Compound 1 was able to inhibit the COX-2 expression in RAW264.7 macrophages exposed to lipopolysaccharide, a pro-inflammatory stimulus. RT-qPCR and luciferase reporter assays suggested that compound 1 reduces COX-2 expression at the transcriptional level. Further studies highlighted the capability of compound 1 to suppress the LPS-induced p38MAPK, JNK, and C/EBPβ phosphorylation, leading to COX-2 down-regulation in RAW264.7 macrophages.
فهرسة مساهمة: Keywords: C/EBPβ; COX-2; JNK; Magydaris pastinacea; benzofurans; p38MAPK
المشرفين على المادة: 0 (Benzofurans)
0 (CCAAT-Enhancer-Binding Protein-beta)
EC 1.14.99.1 (Cyclooxygenase 2)
0 (Glycosides)
0 (Lipopolysaccharides)
0 (NF-kappa B)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
EC 2.7.12.2 (MAP Kinase Kinase 4)
تواريخ الأحداث: Date Created: 20231207 Date Completed: 20240131 Latest Revision: 20240131
رمز التحديث: 20240131
DOI: 10.1080/14756366.2023.2287420
PMID: 38058285
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-6374
DOI:10.1080/14756366.2023.2287420