دورية أكاديمية
Oxide nanoparticles based in magnesium as a potential dental tool to inhibit bacterial activity and promote osteoblast viability.
| العنوان: | Oxide nanoparticles based in magnesium as a potential dental tool to inhibit bacterial activity and promote osteoblast viability. |
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| المؤلفون: | Vega-Jiménez AL; Laboratorio de Bioingeniería de Tejidos. Facultad de Odontología, Universidad Nacional Autónoma de México., González-Alva P; Laboratorio de Bioingeniería de Tejidos. Facultad de Odontología, Universidad Nacional Autónoma de México., Rodríguez-Hernández AP; Laboratorio de Genética Molecular Facultad de Odontología, Universidad Nacional Autónoma de México., Vázquez-Olmos AR; Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México., Paz-Díaz B; Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México. |
| المصدر: | Dental materials journal [Dent Mater J] 2024 Jan 30; Vol. 43 (1), pp. 11-19. Date of Electronic Publication: 2023 Dec 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Society for Dental Materials and Devices Country of Publication: Japan NLM ID: 8309299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1361 (Electronic) Linking ISSN: 02874547 NLM ISO Abbreviation: Dent Mater J |
| أسماء مطبوعة: | Original Publication: Tokyo-to : Japanese Society for Dental Materials and Devices, [1982?- |
| مواضيع طبية MeSH: | Magnesium Oxide*/pharmacology , Nanoparticles*/chemistry, Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Escherichia coli ; Mammals ; Microbial Sensitivity Tests ; Oxides ; Spectroscopy, Fourier Transform Infrared |
| مستخلص: | Functional nano-fillers are commonly used to reduce bacterial colonization in dentistry. This study aimed to synthesize, characterize, and evaluate the biological effects of magnesium oxide (MgO) nanoparticles (NP) obtained by mechanosynthesis. XRD, TEM, FT-IR, and UV-Vis were used to characterize MgO-NP which were subsequently tested for their activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli (E. coli). The effects of MgO-NP on osteoblast cells were also analyzed. Three variables were studied: microbial inhibition by optical density (OD; 570-nm), viability estimated by colony-forming-units, and cell proliferation. The characterization of NP is consistent with nanostructures, minimum inhibitory concentration between 1.5-5 mg/mL, and microbial inhibition at 9.75 ug/mL concentration for E. coli were determined. There were different concentration-dependent effects on cell proliferation. Results were observed with 0.156 mg/mL MgO-NP, which increased cell proliferation at 24 and 48 h. The results suggest the antibacterial suitability of MgO-NP, with tolerable viability of mammalian cells for dental applications. |
| فهرسة مساهمة: | Keywords: Antimicrobial; Magnesium oxide; Mechanosynthesis; Nanoparticles; Osteoblast cytotoxicity |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 3A3U0GI71G (Magnesium Oxide) 0 (Oxides) |
| تواريخ الأحداث: | Date Created: 20231210 Date Completed: 20240208 Latest Revision: 20240208 |
| رمز التحديث: | 20240209 |
| DOI: | 10.4012/dmj.2023-041 |
| PMID: | 38072414 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1881-1361 |
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| DOI: | 10.4012/dmj.2023-041 |