دورية أكاديمية
Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy.
| العنوان: | Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy. |
|---|---|
| المؤلفون: | Dang BN; College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea., Kwon TK; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea., Lee S; College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea., Jeong JH; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: jeeheon@skku.edu., Yook S; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: ysimmyung@skku.edu. |
| المصدر: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Jan; Vol. 365, pp. 773-800. Date of Electronic Publication: 2023 Dec 14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| مواضيع طبية MeSH: | Neoplasms*/therapy , Nanoparticles*/chemistry, Humans ; Immunotherapy ; Nanotechnology ; T-Lymphocytes |
| مستخلص: | Cancer immunotherapy is a groundbreaking strategy that has revolutionized the field of oncology compared to other therapeutic strategies, such as surgery, chemotherapy, or radiotherapy. However, cancer complexity, tumor heterogeneity, and immune escape have become the main hurdles to the clinical application of immunotherapy. Moreover, conventional immunotherapies cause many harmful side effects owing to hyperreactivity in patients, long treatment durations and expensive cost. Nanotechnology is considered a transformative approach that enhances the potency of immunotherapy by capitalizing on the superior physicochemical properties of nanocarriers, creating highly targeted tissue delivery systems. These advantageous features include a substantial specific surface area, which enhances the interaction with the immune system. In addition, the capability to finely modify surface chemistry enables the achievement of controlled and sustained release properties. These advances have significantly increased the potential of immunotherapy, making it more powerful than ever before. In this review, we introduce recent nanocarriers for application in cancer immunotherapy based on strategies that target different main immune cells, including T cells, dendritic cells, natural killer cells, and tumor-associated macrophages. We also provide an overview of the role and significance of nanotechnology in cancer immunotherapy. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomaterials; Cancer immunotherapy; Nanomedicine; Nanotechnology; cancer vaccines |
| تواريخ الأحداث: | Date Created: 20231211 Date Completed: 20240131 Latest Revision: 20240131 |
| رمز التحديث: | 20240131 |
| DOI: | 10.1016/j.jconrel.2023.12.007 |
| PMID: | 38081328 |
| قاعدة البيانات: | MEDLINE |
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