دورية أكاديمية
أعرض في EDS

Evidence for Rho-dependent control of a virulence switch in Acinetobacter baumannii .

التفاصيل البيبلوغرافية
العنوان: Evidence for Rho-dependent control of a virulence switch in Acinetobacter baumannii .
المؤلفون: Pérez-Varela M; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA., Singh R; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA., Colquhoun JM; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.; Research Service, Atlanta VA Medical Center, Decatur, Georgia, USA., Starich OG; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA., Tierney ARP; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA., Tipton KA; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA., Rather PN; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.; Research Service, Atlanta VA Medical Center, Decatur, Georgia, USA.; Emory Antibiotic Resistance Center, Emory University, Atlanta, Georgia, USA.
المصدر: MBio [mBio] 2024 Jan 16; Vol. 15 (1), pp. e0270823. Date of Electronic Publication: 2023 Dec 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Society for Microbiology
مواضيع طبية MeSH: Acinetobacter baumannii*/genetics , Acinetobacter Infections*/microbiology, Humans ; Virulence ; Pandemics
مستخلص: Importance: Acinetobacter baumannii is a significant cause of infections in the healthcare setting. More recently, A. baumannii has been a leading cause of secondary bacterial pneumonia in patients infected with SARS-CoV-2 and the overall frequency of A. baumannii infection increased 78% during the COVID-19 pandemic. A. baumannii can exist in virulent or avirulent subpopulations and this interconversion is mediated by the expression of a family of TetR-type transcriptional regulators. In this study, we demonstrate that Rho is a key regulatory component in the expression of these TetR regulators. Overall, this study is the first to address a role for Rho in A. baumannii and provides additional evidence for the role of Rho in regulating diversity in bacterial subpopulations.
Competing Interests: The authors declare no conflict of interest.
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معلومات مُعتمدة: I01 BX001725 United States BX BLRD VA; IK2 BX005911 United States BX BLRD VA; IK6 BX004470 United States BX BLRD VA
فهرسة مساهمة: Keywords: Acinetobacter baumannii; Rho-dependent termination; TetR regulator transcriptional regulator; phenotypic heterogeneity
تواريخ الأحداث: Date Created: 20231212 Date Completed: 20240117 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10790780
DOI: 10.1128/mbio.02708-23
PMID: 38085026
قاعدة البيانات: MEDLINE
الوصف
تدمد:2150-7511
DOI:10.1128/mbio.02708-23