دورية أكاديمية
أعرض في EDS

Age at cardiovascular disease onset, dementia risk, and the role of lifestyle factors.

التفاصيل البيبلوغرافية
العنوان: Age at cardiovascular disease onset, dementia risk, and the role of lifestyle factors.
المؤلفون: van Gennip ACE; Epidemiology of Ageing and Neurodegenerative Diseases, Inserm U1153, Université Paris Cité, Paris, France.; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.; School for Cardiovascular Diseases CARIM, Maastricht University, Maastricht, The Netherlands., van Sloten TT; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Fayosse A; Epidemiology of Ageing and Neurodegenerative Diseases, Inserm U1153, Université Paris Cité, Paris, France., Sabia S; Epidemiology of Ageing and Neurodegenerative Diseases, Inserm U1153, Université Paris Cité, Paris, France.; Faculty of Brain Sciences, University College London, London, UK., Singh-Manoux A; Epidemiology of Ageing and Neurodegenerative Diseases, Inserm U1153, Université Paris Cité, Paris, France.; Faculty of Brain Sciences, University College London, London, UK.
المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Mar; Vol. 20 (3), pp. 1693-1702. Date of Electronic Publication: 2023 Dec 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.
مواضيع طبية MeSH: Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/prevention & control , Dementia*/epidemiology, Humans ; Aged ; Middle Aged ; Risk Factors ; Prospective Studies ; Life Style
مستخلص: Introduction: We first examined the role of age at cardiovascular disease (CVD) onset for incident dementia, and then examined whether lifestyle factors at guideline-recommended levels in individuals with CVD mitigates dementia risk.
Methods: We used population-based data (Whitehall II: n = 10,308/baseline 1985-1988/examinations every 4-5 years). Lifestyle factors (non-smoking, body mass index [BMI], physical activity, diet) were extracted post-CVD.
Results: Over a median of 31.6 years, 3275 (32.1%) developed CVD. At age 70, risk of dementia was higher in individuals with CVD onset before (hazard ratio [HR] of incident dementia for participants with CVD before age 60, using participants without CVD at age 70 as the reference: 1.56, 95% confidence interal [CI] 1.18-2.08) but not after 60 years. In participants with CVD, a greater number of lifestyle factors at recommended levels post-CVD was associated with a lower dementia risk (per lifestyle factor at recommended level HR: 0.73, 95% CI 0.59-0.92).
Discussion: Our results suggest that early onset CVD is associated with a higher dementia risk at older ages. In those with CVD, the dementia risk was lower if lifestyle factors are at recommended levels following CVD diagnosis.
Highlights: CVD in midlife but not in late life is associated with a higher risk of dementia. Dementia risk in CVD patients is lower if their lifestyle factors are at recommended levels. These findings provide evidence to promote CVD prevention in midlife or earlier. Study findings also show the importance of a healthy lifestyle in those with CVD.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
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معلومات مُعتمدة: MR/R024227/1 United Kingdom MRC_ Medical Research Council; RF1 AG062553 United States AG NIA NIH HHS; RF1AG062553 United States NH NIH HHS; 221854/Z/20/Z United Kingdom WT_ Wellcome Trust; MR/S011676/1 United Kingdom MRC_ Medical Research Council; R01 AG056477 United States AG NIA NIH HHS; United Kingdom WT_ Wellcome Trust; R01AG056477 United States NH NIH HHS
فهرسة مساهمة: Keywords: age at onset; cardiovascular disease; dementia; epidemiology; lifestyle factors
تواريخ الأحداث: Date Created: 20231212 Date Completed: 20240318 Latest Revision: 20240715
رمز التحديث: 20240716
مُعرف محوري في PubMed: PMC10947967
DOI: 10.1002/alz.13562
PMID: 38085549
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-5279
DOI:10.1002/alz.13562