دورية أكاديمية
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The effects of thioredoxin peroxidase from Cysticercus cellulosae excretory-secretory antigens on TGF-β signaling pathway and Th17 cells differentiation in Jurkat cells by transcriptomics.

التفاصيل البيبلوغرافية
العنوان: The effects of thioredoxin peroxidase from Cysticercus cellulosae excretory-secretory antigens on TGF-β signaling pathway and Th17 cells differentiation in Jurkat cells by transcriptomics.
المؤلفون: Sun X; Department of Parasitology, Zunyi Medical University, Zunyi, China., Mu Q; Department of Parasitology, Zunyi Medical University, Zunyi, China., Yang F; Department of Parasitology, Zunyi Medical University, Zunyi, China., Liu M; Department of Parasitology, Zunyi Medical University, Zunyi, China., Zhou B; Department of Parasitology, Zunyi Medical University, Zunyi, China. 1458030871@qq.com.
المصدر: Parasitology research [Parasitol Res] 2023 Dec 14; Vol. 123 (1), pp. 50. Date of Electronic Publication: 2023 Dec 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH: Cysticercus* , Th17 Cells*, Humans ; Animals ; Swine ; Jurkat Cells ; Peroxiredoxins ; Cell Differentiation ; Gene Expression Profiling ; T-Lymphocytes, Regulatory ; Signal Transduction ; Transforming Growth Factor beta
مستخلص: Thioredoxin peroxidase (TPx) protein from the excretory-secretory antigens (ESAs) of Cysticercus cellulosae (C. cellulosae) has been shown to regulate the differentiation of host Treg and Th17 cells, resulting in an immunosuppressive response dominated by Treg cells. However, the molecular mechanism by which TPx protein from the ESAs of C. cellulosae regulates the imbalance of host Treg/Th17 cell differentiation has not been reported. TPx protein from porcine C. cellulosae ESAs was used to stimulate Jurkat cells activated with PMA and ionomycin at 0, 24, 48, and 72 h. Transcriptomic analysis was performed to investigate the signaling pathways associated with Jurkat cells differentiation regulated by TPx protein from C. cellulosae ESAs. Gene Set Enrichment Analysis (GSEA) revealed that TPx protein from porcine C. cellulosae ESAs could induce upregulation of the TGF-β signaling pathway and downregulation of Th17 cell differentiation in Jurkat cells. TPx protein from porcine C. cellulosae ESAs can activate the TGF-β signaling pathway in Jurkat cells, thereby regulating the differentiation of Treg/Th17 cells and leading to an immunosuppressive response dominated by Treg cells, enabling evasion of the host immune attack. This study provides a foundation for further validation of these pathways and further elucidates the molecular mechanisms underlying immune evasion caused by porcine C. cellulosae.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Cysticercus cellulosae; Signaling pathways; T cell immune response; Thioredoxin peroxidase; Transcriptomics
المشرفين على المادة: EC 1.11.1.15 (Peroxiredoxins)
0 (Transforming Growth Factor beta)
تواريخ الأحداث: Date Created: 20231214 Date Completed: 20231216 Latest Revision: 20240202
رمز التحديث: 20240202
DOI: 10.1007/s00436-023-08075-z
PMID: 38095704
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1955
DOI:10.1007/s00436-023-08075-z